Effects of levomepromazine and different desflurane concentrations upon electrocardiographic variables in dogs

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dc.contributor.authorNunes, N.
dc.contributor.authorRezende, M. L.
dc.contributor.authorSantos, PSP
dc.contributor.authorMartins, SEC
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:13:57Z
dc.date.available2014-05-20T13:13:57Z
dc.date.issued2004-01-01
dc.description.abstractObjectives To investigate the effects of levomepromazine and different desflurane concentrations upon electrocardiographic variables.Animals Twenty adult mongrel dogs of both sexes weighing 6-28 kg.Methods Dogs were divided into two groups of 10 animals. Group I received 1 mg kg(-1) lV of levomepromazine and 15 minutes later anesthesia was induced with propofol (3 mg kg(-1) IV). Desflurane end-tidal concentration was set at 1.6 MAC. After 30 minutes at this concentration, measurements were taken and the end-tidal concentration was reduced to 1.4 MAC. Thereafter, it was reduced to 1.2 and then 1.0 MAC at 1.5-minute intervals. The same procedure was followed for group 2, except that levomepromazine was replaced with 0.2 mL kg(-1) of 0.9% saline solution and more propofol was needed for induction (7 mg kg(-1)). The animals' body temperature was maintained between 38.3 and 39 degreesC using a heating pad. The electrocardiographic tracing was obtained from lead II throughout the experimental period. The measurements were taken immediately before the administration of levomepromazine or placebo (T-1), 15 minutes after pre-medication (T-2) and 30 minutes after the establishment of 1.6 MAC (T-3)The other measurements were made at the concentrations of 1.4, 1.2, and 1.0 MAC, respectively (T4-6). The numerical data were submitted to analysis of variance plus F-test (p < 0.05).Results the dogs that received levomepromazine had a decrease in heart rate. However, in both groups it increased with desflurane administration. Levomepromazine, in association with desflurane, did not induce significant electrocardiographic changes, and all mean values (except P-wave duration) were within the reference range for this species.Conclusions and clinical relevance This study documented that levomepromazine, in association with desflurane, does not induce significant changes in electrocardiographic variables, suggesting that this drug combination has minimal effect on myocardial conduction.en
dc.description.affiliationUNESP, FCAV, Dept Clin & Cirurgia Vet, BR-14870000 Jaboticabal, SP, Brazil
dc.description.affiliationUnespUNESP, FCAV, Dept Clin & Cirurgia Vet, BR-14870000 Jaboticabal, SP, Brazil
dc.format.extent73-77
dc.identifierhttp://dx.doi.org/10.1111/j.1467-2995.2004.00124.x
dc.identifier.citationVeterinary Anaesthesia and Analgesia. Oxford: Blackwell Publishing Ltd, v. 31, n. 1, p. 73-77, 2004.
dc.identifier.doi10.1111/j.1467-2995.2004.00124.x
dc.identifier.issn1467-2987
dc.identifier.lattes0023783814889740
dc.identifier.urihttp://hdl.handle.net/11449/1577
dc.identifier.wosWOS:000188981000009
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofVeterinary Anaesthesia and Analgesia
dc.relation.ispartofjcr2.064
dc.relation.ispartofsjr0,800
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectdesfluranept
dc.subjectdogspt
dc.subjectelectrocardiographypt
dc.subjectlevomepromazinept
dc.titleEffects of levomepromazine and different desflurane concentrations upon electrocardiographic variables in dogsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing Ltd
unesp.author.lattes0023783814889740
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
unesp.departmentClínica e Cirurgia Veterinária - FCAVpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias