Risk factors for amenorrhea in juvenile systemic lupus erythematosus (JSLE): a Brazilian multicentre cohort study

dc.contributor.authorSilva, C. A. A.
dc.contributor.authorHilario, M. O.
dc.contributor.authorFebronio, M. V.
dc.contributor.authorOliveira, S. K.
dc.contributor.authorTerreri, M. T.
dc.contributor.authorSacchetti, S. B.
dc.contributor.authorSztajnbok, F. R.
dc.contributor.authorMarini, R.
dc.contributor.authorQuintero, M. V.
dc.contributor.authorBica, B. E.
dc.contributor.authorPereira, R. M.
dc.contributor.authorBonfa, E.
dc.contributor.authorFerriani, V. P.
dc.contributor.authorRobazzi, T. C.
dc.contributor.authorMagalhães, Cláudia Saad [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionSanta Casa São Paulo
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionSanta Casa Belo Horizonte
dc.contributor.institutionHosp Sao Rafael Bahia
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:28:50Z
dc.date.available2014-05-20T15:28:50Z
dc.date.issued2007-01-01
dc.description.abstractWe evaluated the prevalence and clinical associations of amenorrhea in 298 female juvenile systemic lupus erythematosus (JSLE) patients (ACR criteria) followed in 12 Brazilian Paediatric Rheumatology centres. Amenorrhea was observed in 35 patients (11.7%) with a mean duration of 7.2 +/- 3.6 months. The hormones were performed in 32/35 patients and none of them had FSH and LH levels above and estradiol below the normal range according to pubertal changes. JSLE patients with amenorrhea were younger (15.04 +/- 2.5 versus 17.8 +/- 3.1 years; P = 0.001), and had a shorter period of time between menarche and current age (3.4 +/- 2.9 versus 6.7 +/- 5.4 years; P = 0.001). Interestingly, the frequency, cumulative dose, number of pulses and duration of intravenous cyclophosphamide treatment were alike in patients with and without amenorrhea (P > 0.05). In contrast, patients with amenorrhea had significantly higher SLEDAI (P = 0.01) and SLICC/ACR-DI (P = 0.024) scores compared to those without this condition. Independent risk factors identified by multivariate analysis were higher SLEDAI (OR=1.059; CI=1.004-1.116; P=0.034) and SLICC/ACR-DI (OR=2.125; IC = 1.373-3.291; P = 0.001) scores. Our data suggest that in spite of imummosuppressive therapy, JSLE patients have an adequate ovarian follicular reserve and amenorrhea is particularly associated with disease activity and damage.en
dc.description.affiliationUniv São Paulo, Pediat Rheumatol Unit, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv Fed São Paulo, São Paulo, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Div Rheumatol, BR-21941 Rio de Janeiro, Brazil
dc.description.affiliationSanta Casa São Paulo, São Paulo, Brazil
dc.description.affiliationUniv Estado Rio de Janeiro, Rio de Janeiro, Brazil
dc.description.affiliationUniv Estadual Campinas, Campinas, Brazil
dc.description.affiliationSanta Casa Belo Horizonte, Minas Gerais, Brazil
dc.description.affiliationUniv São Paulo, Div Rheumatol, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationHosp Sao Rafael Bahia, Salvador, Brazil
dc.description.affiliationSão Paulo State Univ, Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Botucatu, SP, Brazil
dc.format.extent531-536
dc.identifierhttp://dx.doi.org/10.1177/0961203307079300
dc.identifier.citationLupus. London: Sage Publications Ltd, v. 16, n. 7, p. 531-536, 2007.
dc.identifier.doi10.1177/0961203307079300
dc.identifier.issn0961-2033
dc.identifier.lattes7098310008371632
dc.identifier.orcid0000-0002-7631-7093
dc.identifier.urihttp://hdl.handle.net/11449/38575
dc.identifier.wosWOS:000248838600011
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.isnodouble34669*
dc.relation.ispartofLupus
dc.relation.ispartofjcr2.969
dc.relation.ispartofsjr1,410
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectadolescentpt
dc.subjectamenorrheapt
dc.subjectcyclophosphamidept
dc.subjectgonadal functionpt
dc.subjectjuvenile systemic lupus erythematosuspt
dc.titleRisk factors for amenorrhea in juvenile systemic lupus erythematosus (JSLE): a Brazilian multicentre cohort studyen
dc.typeArtigo
dcterms.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dcterms.rightsHolderSage Publications Ltd
unesp.author.lattes7098310008371632[15]
unesp.author.orcid0000-0002-7631-7093[15]
unesp.author.orcid0000-0002-2426-716X[4]
unesp.author.orcid0000-0002-3723-5028[11]
unesp.author.orcid0000-0002-0520-4681[12]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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