Dose–response effect of Montelukast on post-extraction dental socket repair and skeletal phenotype of mice

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dc.contributor.authorRibeiro, Kim Henderson Carmo [UNESP]
dc.contributor.authorda Silva, Raquel Barroso Parra [UNESP]
dc.contributor.authorRoseno, Ana Carolyna Becher [UNESP]
dc.contributor.authorBarreto, Ana Julia Moreno [UNESP]
dc.contributor.authorBacelar, Ana Carolina Zucon [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorDuarte, Marco Antônio Húngaro
dc.contributor.authorFakhouri, Walid D.
dc.contributor.authorChaves-Neto, Antonio Hernandes [UNESP]
dc.contributor.authorBiguetti, Cláudia Cristina
dc.contributor.authorMatsumoto, Mariza Akemi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionThe University of Texas at Health Science Center at Houston (UTH)
dc.contributor.institutionThe University of Texas at Rio Grande Valley (UTRGV)
dc.date.accessioned2023-07-29T13:46:16Z
dc.date.available2023-07-29T13:46:16Z
dc.date.issued2023-01-01
dc.description.abstractBone metabolism and repair are directly regulated by arachidonic acid metabolites. At present, we analyzed the dose–response effects of a selective cysteinyl leukotriene receptor type-1 antagonist during bone repair after tooth extraction and on non-injured skeleton. Sixty-three 129 Sv/Ev male mice composed the groups: C—Control (saline solution); MTK2—2 mg/Kg of Montelukast (MTK) and MTK4–4 mg/Kg of MTK, daily administered by mouth throughout all experimental periods set at 7, 14, and 21 days post-operative. Dental sockets were analyzed by computed microtomography (microCT), histopathology, and immunohistochemistry. Femurs, L5 vertebra and organs were also removed for observation. Blood was collected for plasma bone and liver markers. Histopathology and microCT analysis revealed early socket repair of MTK2 and MTK4 animals, with significant increased BV/TV at days 14 and 21 compared to C. Higher plasma calcium was detected at days 7 and 21 in MTK4 in comparison to C, while phosphate was significantly increased in MTK2 in the same periods in comparison to C and MTK4. No significant differences were found regarding plasma ALP and TRAP, neither for local TRAP and Runx2 immunolabeling at the healing sockets. Organs did not present histological abnormalities. Increased AST levels have been detected in distinct groups and periods. In general, femur phenotype was improved in MTK treated animals. Collectively, MTK promoted early bone formation after tooth extraction and increased bone quality of femurs and vertebra in a time-dose-dependent manner, and should be considered as an alternative therapy when improved post-extraction socket repair or skeleton preservation is required.en
dc.description.affiliationDepartment of Oral Surgery and Dental Clinics Araçatuba School of Dentistry São Paulo State University—Unesp, Rua José Bonifácio 1192, São Paulo
dc.description.affiliationDepartment of Basic Sciences Araçatuba School of Dentistry SãoPauloStateUniversity-Unesp, Rua José Bonifácio 1192, São Paulo
dc.description.affiliationDepartment of DentistryEndodontics and Dental MaterialsSchool of Dentistry University of São Paulo Alameda Otávio Pinheiro Brisola, 9-20, São Paulo
dc.description.affiliationSchool of Dentistry The University of Texas at Health Science Center at Houston (UTH), 1941 East Road
dc.description.affiliationSchool of Podiatric Medicine The University of Texas at Rio Grande Valley (UTRGV), 2120 Treasure Hills Blvd. Harlingen
dc.description.affiliationUnespDepartment of Oral Surgery and Dental Clinics Araçatuba School of Dentistry São Paulo State University—Unesp, Rua José Bonifácio 1192, São Paulo
dc.description.affiliationUnespDepartment of Basic Sciences Araçatuba School of Dentistry SãoPauloStateUniversity-Unesp, Rua José Bonifácio 1192, São Paulo
dc.identifierhttp://dx.doi.org/10.1007/s10266-023-00800-5
dc.identifier.citationOdontology.
dc.identifier.doi10.1007/s10266-023-00800-5
dc.identifier.issn1618-1255
dc.identifier.issn1618-1247
dc.identifier.scopus2-s2.0-85150175626
dc.identifier.urihttp://hdl.handle.net/11449/248520
dc.language.isoeng
dc.relation.ispartofOdontology
dc.sourceScopus
dc.subject5-Leukotriene
dc.subjectBone tissue
dc.subjectCysteinyl leukotrienes
dc.subjectDental socket
dc.subjectMice
dc.titleDose–response effect of Montelukast on post-extraction dental socket repair and skeletal phenotype of miceen
dc.typeArtigo
unesp.author.orcid0000-0001-5389-0105[11]

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Artigos - Cirurgia e Clínica Integrada - FOA
Artigos - Ciências Básicas - FOA