Review of Fluconazole Properties and Analytical Methods for Its Determination

Página do item simplificado
dc.contributor.authorRuela Correa, Josilene Chaves [UNESP]
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:33:43Z
dc.date.available2014-05-20T15:33:43Z
dc.date.issued2011-01-01
dc.description.abstractFluconazole, -(2.4-diflurofenil)--(1H-triazol-1-methyl)-1H-1,2,4-triazol-1-ethanol, is an antifungal of triazoles class. It shows activity against species of Candida sp., and it is indicated in cases of oropharyngeal candidiasis, esophageal, vaginal, and deep infection. Fluconazole is a selective inhibitor of ergosterol, a steroid exclusive of the cell membrane of fungal cells. Fluconazole is highly absorbed by the gastrointestinal tract, and it spreads easily by body fluids. The main adverse reactions related to the use of fluconazole are nausea, vomiting, headache, rash, abdominal pain, diarrhea, and alopecia in patients undergoing prolonged treatment with a dose of 400 mg/day. In the form of raw material, pharmaceutical formulations, or biological material, fluconazole can be determined by methods such as titration, spectrophotometry, and thin-layer, gas, and liquid chromatography. This article discusses the pharmacological and physical-chemical properties of fluconazole and also the methods of analysis applied to the determination of the drug.en
dc.description.affiliationUNESP, Univ Estadual Paulista Julio de Mesquita Filho, Fac Ciencias Farmaceut Araraquara, Programa Posgrad Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationFac Ciencias Farmaceut Araraquara, Dept Farmacos & Medicamentos, São Paulo, SP, Brazil
dc.description.affiliationUnespUNESP, Univ Estadual Paulista Julio de Mesquita Filho, Fac Ciencias Farmaceut Araraquara, Programa Posgrad Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.format.extent124-132
dc.identifierhttp://dx.doi.org/10.1080/10408347.2011.557980
dc.identifier.citationCritical Reviews In Analytical Chemistry. Philadelphia: Taylor & Francis Inc, v. 41, n. 2, p. 124-132, 2011.
dc.identifier.doi10.1080/10408347.2011.557980
dc.identifier.issn1040-8347
dc.identifier.urihttp://hdl.handle.net/11449/42275
dc.identifier.wosWOS:000290398100004
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofCritical Reviews in Analytical Chemistry
dc.relation.ispartofjcr3.231
dc.relation.ispartofsjr0,819
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectReviewen
dc.subjectfluconazoleen
dc.subjectanalytical methodsen
dc.titleReview of Fluconazole Properties and Analytical Methods for Its Determinationen
dc.typeResenha
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.orcid0000-0002-0385-340X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Araraquara - FCF - Faculdade de Ciências Farmacêuticas