Antineoplastic agents exacerbate periodontal inflammation and aggravate experimental periodontitis

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dc.contributor.authorGusman, David Jonathan Rodrigues [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorTheodoro, Letícia Helena [UNESP]
dc.contributor.authorGarcia, Valdir Gouveia [UNESP]
dc.contributor.authorNagata, Maria José Hitomi [UNESP]
dc.contributor.authorAlves, Breno Edson Sendão [UNESP]
dc.contributor.authorde Araujo, Nathalia Januario [UNESP]
dc.contributor.authorMatheus, Henrique Rinaldi [UNESP]
dc.contributor.authorde Almeida, Juliano Milanezi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Western São Paulo (UNOESTE)
dc.contributor.institutionMaringa University Center (UNINGA)
dc.date.accessioned2019-10-06T17:08:18Z
dc.date.available2019-10-06T17:08:18Z
dc.date.issued2019-04-01
dc.description.abstractAim: This study evaluated the effects of 5-fluorouracil (5-FU) and cisplatin (CIS) in healthy periodontal tissues and in the early stages of experimental periodontitis (EP) in rats. Methods: One hundred and eighty male rats were divided into three groups, which were submitted to the following systemic treatments: physiological saline solution (PSS); CIS and 5FU. Each group was subdivided into two subgroups: without (NEP) and with (EP) induction of EP. Animals were euthanized at 3, 5 and 7 days post-treatment. Histological, histometric (percentage of bone in the furcation [PBF]) and immunohistochemical (for tumour necrosis factor-α, interleukin-1β and receptor activator of nuclear factor-κB ligand) analyses were performed. Data were statistically analysed. Results: CIS-NEP and 5FU-NEP showed more inflammation than PSS-NEP at 3, 5 and 7 days. CIS-EP and 5FU-EP showed more inflammation and lower PBF than PSS-EP at all periods of evaluation. 5FU-EP showed lower PBF than CIS-EP at 5 and 7 days. Conclusion: 5-FU and CIS exacerbated periodontal inflammation and aggravated the progression of EP in its early stages.en
dc.description.affiliationDepartment of Surgery and Integrated Clinic – Division of Periodontics School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationDepartment of Periodontics University of Western São Paulo (UNOESTE)
dc.description.affiliationDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationDepartment of Periodontics Maringa University Center (UNINGA)
dc.description.affiliationUnespDepartment of Surgery and Integrated Clinic – Division of Periodontics School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2014/11427-8
dc.format.extent457-469
dc.identifierhttp://dx.doi.org/10.1111/jcpe.13101
dc.identifier.citationJournal of Clinical Periodontology, v. 46, n. 4, p. 457-469, 2019.
dc.identifier.doi10.1111/jcpe.13101
dc.identifier.issn1600-051X
dc.identifier.issn0303-6979
dc.identifier.lattes4408095517346846
dc.identifier.lattes4774447118127346
dc.identifier.lattes8399870097572073
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.scopus2-s2.0-85064931892
dc.identifier.urihttp://hdl.handle.net/11449/190286
dc.language.isoeng
dc.relation.ispartofJournal of Clinical Periodontology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectalveolar bone loss
dc.subjectantineoplastic agents
dc.subjectcisplatin
dc.subjectfluorouracil
dc.subjectperiodontal disease
dc.subjectperiodontium
dc.titleAntineoplastic agents exacerbate periodontal inflammation and aggravate experimental periodontitisen
dc.typeArtigo
unesp.advisor.lattes4408095517346846[2]
unesp.author.lattes4774447118127346
unesp.author.lattes8399870097572073
unesp.author.orcid0000-0003-0071-1630[1]
unesp.author.orcid0000-0003-4859-0583[2]

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Artigos - Ciências Básicas - FOA
Artigos - Cirurgia e Clínica Integrada - FOA