Modular 3D-printed fluorometer/photometer for determination of iron(ii), caffeine, and ciprofloxacin in pharmaceutical samples

Página do item simplificado
dc.contributor.authorLamarca, Rafaela Silva [UNESP]
dc.contributor.authorSilva, João Pedro [UNESP]
dc.contributor.authorVaroni dos Santos, João Paulo [UNESP]
dc.contributor.authorAyala-Durán, Saidy Cristina [UNESP]
dc.contributor.authorLima Gomes, Paulo Clairmont Feitosa de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:53:49Z
dc.date.available2023-07-29T13:53:49Z
dc.date.issued2023-04-17
dc.description.abstractThe demand for the development of portable and low-cost analytical devices has encouraged studies employing additive manufacturing techniques, such as 3D-printing. This method can be used to produce components such as printed electrodes, photometers, and fluorometers for low-cost systems that provide advantages including low sample volume, reduced chemical waste, and easy coupling with LED-based optics and other instrumental devices. In the present work, a modular 3D-printed fluorometer/photometer was designed and applied for the determination of caffeine (CAF), ciprofloxacin (CIP), and Fe(ii) in pharmaceutical samples. All the plastic parts were printed separately by a 3D printer, using Tritan as the plastic material (black color). The final size of the modular 3D-printed device was 12 × 8 cm. The radiation sources were light-emitting diodes (LEDs), while a light dependent resistor (LDR) was used as a photodetector. The analytical curves obtained for the device were: y = 3.00 × 10−4 [CAF] + 1.00 and R2 = 0.987 for caffeine; y = 6.90 × 10−3 [CIP] − 3.39 × 10−2 and R2 = 0.991 for ciprofloxacin; and y = 1.12 × 10−1 [Fe(ii)] + 1.26 × 10−2 and R2 = 0.998 for iron(ii). The results obtained using the developed device were compared with reference methods, with no statistically significant differences observed. The 3D-printed device was composed of moveable parts, providing flexibility for adaptation and application as a photometer or fluorometer, by only switching the photodetector position. The LED could also be easily switched, permitting application of the device for different purposes. The cost of the device, including the printing and electronic components, was lower than US$10. The use of 3D-printing enables the development of portable instruments for use in remote locations with a lack of research resources.en
dc.description.affiliationDepartment of Analytical Chemistry Physical Chemistry and Inorganic Chemistry National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry São Paulo State University (UNESP), São Paulo
dc.description.affiliationUnespDepartment of Analytical Chemistry Physical Chemistry and Inorganic Chemistry National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry São Paulo State University (UNESP), São Paulo
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Goiás
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Piauí
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent12050-12058
dc.identifierhttp://dx.doi.org/10.1039/d3ra01281f
dc.identifier.citationRSC Advances, v. 13, n. 18, p. 12050-12058, 2023.
dc.identifier.doi10.1039/d3ra01281f
dc.identifier.issn2046-2069
dc.identifier.scopus2-s2.0-85158057993
dc.identifier.urihttp://hdl.handle.net/11449/248789
dc.language.isoeng
dc.relation.ispartofRSC Advances
dc.sourceScopus
dc.titleModular 3D-printed fluorometer/photometer for determination of iron(ii), caffeine, and ciprofloxacin in pharmaceutical samplesen
dc.typeArtigo
unesp.author.orcid0000-0002-8605-8013[1]
unesp.author.orcid0000-0003-1817-0019[2]
unesp.author.orcid0009-0002-0696-791X[3]
unesp.author.orcid0000-0001-6311-891X[4]
unesp.author.orcid0000-0002-4837-6352[5]

Arquivos

Coleções

Artigos - Físico Química - IQ