Mutagenicity of the Musa paradisiaca (Musaceae) fruit peel extract in mouse peripheral blood cells in vivo

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dc.contributor.authorAndrade, C. U. B.
dc.contributor.authorPerazzo, F. F.
dc.contributor.authorMaistro, Edson Luis [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Amapá (UNIFAP)
dc.contributor.institutionUniv Alfenas
dc.date.accessioned2014-05-20T13:31:44Z
dc.date.available2014-05-20T13:31:44Z
dc.date.issued2008-01-01
dc.description.abstractPlants are a source of many biologically active products and nowadays they are of great interest to the pharmaceutical industry. In the present study, the mutagenic potential of the Musa paradisiaca fruit peel extract was assessed by the single-cell gel electrophoresis (SCGE) and micronucleus assays. Animals were treated orally with three different concentrations of the extract (1000, 1500, and 2000 mg/kg body weight). Peripheral blood cells of Swiss mice were collected 24 h after treatment for the SCGE assay and 48 and 72 h for the micronucleus test. The results showed that the two higher doses of the extract of M. paradisiaca induced statistically significant increases in the average numbers of DNA damage in peripheral blood leukocytes for the two higher doses and a significant increase in the mean of micronucleated polychromatic erythrocytes in the three doses tested. The polychromatic/normochromatic erythrocyte ratio scored in the treated groups was not statistically different from the negative control. The data obtained indicate that fruit peel extract from M. paradisiaca showed mutagenic effect in the peripheral blood cells of Swiss albino mice.en
dc.description.affiliationUniv Estadual Paulista, Dept Fonoaudiol, Fac Filosofia & Ciencias, Marilia, SP, Brazil
dc.description.affiliationUniv Fed Amapa, Lab Farmacos, Macapa, PA, Brazil
dc.description.affiliationUniv Alfenas, Fac Enfermagem, Alfenas, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Fonoaudiol, Fac Filosofia & Ciencias, Marilia, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipIdCNPq: 306544/2006-7
dc.description.sponsorshipIdFAPESP: 06/57514-2
dc.description.sponsorshipIdFAPEMIG: EDT - 1879/02
dc.format.extent725-732
dc.identifierhttp://dx.doi.org/10.4238/vol7-3gmr462
dc.identifier.citationGenetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 7, n. 3, p. 725-732, 2008.
dc.identifier.doi10.4238/vol7-3gmr462
dc.identifier.fileWOS000260227100016.pdf
dc.identifier.issn1676-5680
dc.identifier.lattes4787521613038315
dc.identifier.orcid0000-0003-0757-7876
dc.identifier.urihttp://hdl.handle.net/11449/10807
dc.identifier.wosWOS:000260227100016
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectMusa paradisiacaen
dc.subjectSingle-cell gel electrophoresisen
dc.subjectMicronucleus testen
dc.subjectPeripheral blood cellsen
dc.subjectComet assayen
dc.titleMutagenicity of the Musa paradisiaca (Musaceae) fruit peel extract in mouse peripheral blood cells in vivoen
dc.typeArtigo
dcterms.licensehttp://www.geneticsmr.com/node/2
dcterms.rightsHolderFunpec-editora
unesp.author.lattes4787521613038315[3]
unesp.author.orcid0000-0003-0757-7876[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Maríliapt

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Artigos - Fonoaudiologia - FFC