Oxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseases

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dc.contributor.authorLaskoski, Luciane Maria
dc.contributor.authorDittrich, Rosangela Locatelli
dc.contributor.authorValadão, Carlos Augusto Araújo [UNESP]
dc.contributor.authorBrum, Juliana Sperotto
dc.contributor.authorBrandão, Yara
dc.contributor.authorBrito, Harald Fernando Vicente
dc.contributor.authorde Sousa, Renato Silva
dc.contributor.institutionFederal University of Paraná (Curitiba campus)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:27:21Z
dc.date.available2018-12-11T17:27:21Z
dc.date.issued2016-03-01
dc.description.abstractTissue damage caused by oxidative stress is involved in the pathogenesis of several diseases in animals and man, and is believed to play a role in the development of laminitis in horses. The aim of this study was to investigate the oxidative stress associated with laminar lesions in horses with lethal gastrointestinal disorders. Laminar tissue samples of the hoof of 30 horses were used. Tissue samples were divided as follows: six healthy horses (control group-CG), and 24 horses that died after complications of gastrointestinal diseases (group suffering from gastrointestinal disorders-GDG). Superoxide dismutase (SOD2) and nitrotyrosine immunostaining and the severity of laminar lesions were evaluated. Presence of laminar lesions and immunostaining for nitrotyrosine and SOD2 were only evident in horses from the GDG group. Thus, oxidative stress may play a role in the pathogenesis of laminar lesions secondary to gastrointestinal disorders.en
dc.description.affiliationGraduate School in Veterinary Sciences Federal University of Paraná (Curitiba campus), Rua dos Funcionários, 1540
dc.description.affiliationGraduate School in Veterinary Surgery São Paulo State Univ. Júlio de Mesquita Filho - UNESP (Jaboticabal campus), Via de Acesso Professor Paulo Donato Castellane, s/n
dc.description.affiliationGraduate School in Microbiology Parasitology and Patology Federal University of Paraná (Curitiba campus), Avenida Coronel Francisco H. dos Santos, s/n
dc.description.affiliationDepartment of Veterinary Medicine Federal University of Paraná (Curitiba campus), Rua dos Funcionários, 1540
dc.description.affiliationUnespGraduate School in Veterinary Surgery São Paulo State Univ. Júlio de Mesquita Filho - UNESP (Jaboticabal campus), Via de Acesso Professor Paulo Donato Castellane, s/n
dc.format.extent66-72
dc.identifierhttp://dx.doi.org/10.1016/j.vetimm.2016.02.008
dc.identifier.citationVeterinary Immunology and Immunopathology, v. 171, p. 66-72.
dc.identifier.doi10.1016/j.vetimm.2016.02.008
dc.identifier.file2-s2.0-84959019036.pdf
dc.identifier.issn1873-2534
dc.identifier.issn0165-2427
dc.identifier.scopus2-s2.0-84959019036
dc.identifier.urihttp://hdl.handle.net/11449/177834
dc.language.isoeng
dc.relation.ispartofVeterinary Immunology and Immunopathology
dc.relation.ispartofsjr0,680
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectEquine
dc.subjectImmunohistochemistry
dc.subjectLaminitis
dc.subjectNitrotyrosine
dc.subjectSuperoxide dismutase
dc.titleOxidative stress in hoof laminar tissue of horses with lethal gastrointestinal diseasesen
dc.typeArtigo
unesp.author.lattes5566877625835272[3]
unesp.author.orcid0000-0001-5283-7310[3]
unesp.departmentClínica e Cirurgia Veterinária - FCAVpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias