Electrical and mechanical effects of hyoscine butylbromide on the human stomach: a non-invasive approach

dc.contributor.authorAmerico, Madileine F. [UNESP]
dc.contributor.authorMiranda, Jose Ricardo A. [UNESP]
dc.contributor.authorCora, Luciana A. [UNESP]
dc.contributor.authorRomeiro, Fernando G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:49:36Z
dc.date.available2014-05-20T13:49:36Z
dc.date.issued2009-04-01
dc.description.abstractDue to the importance of motility in a number of gastrointestinal disorders, efforts have been made to evaluate both gastric motility counterparts: electrical activity and mechanical activity. The present work aimed to propose a new approach, associating AC biosusceptometry (ACB) and electrogastrography (EGG), to noninvasively monitoring mechanical and electrical gastric activity, respectively. Fourteen volunteers ingested a test meal and their gastric activity was evaluated by EGG and ACB at a baseline and after 20 mg of i.v. hyoscine butylbromide. ACB and EGG showed a similar signal pattern and high temporal correlation. Hyoscine butylbromide decreased the mechanical motility index (MI) by 50.9%, while for electrical MI the reduction was 36.5%. Delayed times to onset (mean +/- SD: 50 +/- 15 versus 40 +/- 20 s; P < 0.01) and the inhibitory effect (16 +/- 4 versus 14 +/- 5 min; P < 0.01) were calculated for ACB and EGG, respectively. ACB and EGG emerged due to their interesting nature, noninvasiveness and low cost to evaluate gastric motility. Our approach associating ACB and EGG allowed monitoring and quantification of the effects of an anticholinergic drug in gastric electrical activity and contractile activity in humans.en
dc.description.affiliationUniv Estadual Paulista, São Paulo State Univ, Inst Biociencias, Dept Fis & Biofis, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, São Paulo State Univ, Fac Med, Dept Clin Med, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, São Paulo State Univ, Inst Biociencias, Dept Fis & Biofis, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, São Paulo State Univ, Fac Med, Dept Clin Med, São Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent363-370
dc.identifierhttp://dx.doi.org/10.1088/0967-3334/30/4/002
dc.identifier.citationPhysiological Measurement. Bristol: Iop Publishing Ltd, v. 30, n. 4, p. 363-370, 2009.
dc.identifier.doi10.1088/0967-3334/30/4/002
dc.identifier.issn0967-3334
dc.identifier.urihttp://hdl.handle.net/11449/17689
dc.identifier.wosWOS:000264813400003
dc.language.isoeng
dc.publisherIop Publishing Ltd
dc.relation.ispartofPhysiological Measurement
dc.relation.ispartofjcr2.006
dc.relation.ispartofsjr0,731
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjecthyoscine N-butylbromideen
dc.subjectstomachen
dc.subjectdiagnostic techniques and procedureen
dc.subjecthumansen
dc.subjectdrug therapyen
dc.titleElectrical and mechanical effects of hyoscine butylbromide on the human stomach: a non-invasive approachen
dc.typeArtigo
dcterms.licensehttp://iopscience.iop.org/info/page/openaccess
dcterms.rightsHolderIop Publishing Ltd
unesp.author.orcid0000-0001-8242-3653[3]
unesp.author.orcid0000-0002-8306-8056[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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