Luminescent threat: toxicity of light stick attractors used in pelagic fishery

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dc.contributor.authorOliveira, Tiago Franco de
dc.contributor.authorMedeiros da Silva, Amanda Lucila
dc.contributor.authorMoura, Rafaela Alves de
dc.contributor.authorBagattini, Raquel [UNESP]
dc.contributor.authorFalcao de Oliveira, Antonio Anax
dc.contributor.authorGennari de Medeiros, Marisa Helena
dc.contributor.authorDi Mascio, Paolo
dc.contributor.authorArruda Campos, Ivan Persio de [UNESP]
dc.contributor.authorBarretto, Fabiano Prado
dc.contributor.authorHenriques Bechara, Etelvino Jose
dc.contributor.authorMelo Loureiro, Ana Paula de
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionGlobal Garbage
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2014-12-03T13:08:50Z
dc.date.available2014-12-03T13:08:50Z
dc.date.issued2014-06-19
dc.description.abstractLight sticks (LS) are sources of chemiluminescence commonly used in pelagic fishery, where hundreds are discarded and reach the shores. Residents from fishing villages report an improper use of LS contents on the skin. Given the scarce information regarding LS toxicity, the effects of LS solutions in cell cultures were evaluated herein. Loss of viability, cell cycle changes and DNA fragmentation were observed in HepG2 cell line and skin fibroblasts. A non-cytotoxic LS concentration increased the occurrence of the mutagenic lesion 1,N-6-epsilon dAdo in HepG2 DNA by three-fold. Additionally, in vitro incubations of spent LS contents with DNA generated dGuo-LS adducts, whose structure elucidation revealed the presence of a reactive chlorinated product. In conclusion, the LS contents were found to be highly cyto- and genotoxic. Our data indicate an urgent need for LS waste management guidelines and for adequate information regarding toxic outcomes that may arise from human exposure.en
dc.description.affiliationUniv Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Ciencias & Saude, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Ciencias Exatas & Tecnol, Sao Paulo, Brazil
dc.description.affiliationGlobal Garbage, Hamburg, Germany
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, Diadema, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Ciencias & Saude, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Ciencias Exatas & Tecnol, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPRPUSP (Pro-Reitoria de Pesquisa da Universidade de Sao Paulo)
dc.description.sponsorshipNAP Redoxoma (PRPUSP)
dc.description.sponsorshipIdFAPESP: 12/21636-8, 2012/08617-4
dc.description.sponsorshipIdFAPESP: 06/56530-4
dc.description.sponsorshipIdFAPESP: 06/57929-8
dc.description.sponsorshipIdFAPESP: 09/54816-6
dc.description.sponsorshipIdFAPESP: 12/08616-8
dc.description.sponsorshipIdFAPESP: 573530/2008-4
dc.description.sponsorshipIdNAP Redoxoma (PRPUSP)2011.1.9352.1.8
dc.description.sponsorshipIdFAPESP: 13/07937-8
dc.format.extent11
dc.identifierhttp://dx.doi.org/10.1038/srep05359
dc.identifier.citationScientific Reports. London: Nature Publishing Group, v. 4, 11 p., 2014.
dc.identifier.doi10.1038/srep05359
dc.identifier.fileWOS000337499400008.pdf
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11449/111615
dc.identifier.wosWOS:000337499400008
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofScientific Reports
dc.relation.ispartofjcr4.122
dc.relation.ispartofsjr1,533
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleLuminescent threat: toxicity of light stick attractors used in pelagic fisheryen
dc.typeArtigo
dcterms.rightsHolderNature Publishing Group
unesp.author.orcid0000-0003-4125-8350[7]
unesp.author.orcid0000-0001-9526-2529[10]
unesp.author.orcid0000-0002-5438-1174[6]

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