Unraveling the Metabolomic Profile and Bioactivities of the Paratoid Gland Secretion from Rhinella granulosa

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dc.contributor.authorBarros, Elcio Daniel S.
dc.contributor.authorMoncao Filho, Evaldo S.
dc.contributor.authorFonseca, Mariluce G.
dc.contributor.authorAlves, Patricia S.
dc.contributor.authorSantos, Antonia Laires S.
dc.contributor.authorFeitosa, Chistiane M.
dc.contributor.authorSilva, Dulce Helena S. [UNESP]
dc.contributor.authorCosta, Pedro Mikael S.
dc.contributor.authorPessoa, Claudia
dc.contributor.authorCampos, Carmem D. L.
dc.contributor.authorMonteiro, Cristina A.
dc.contributor.authorChaves, Mariana Helena
dc.contributor.authorVieira Junior, Gerardo M.
dc.contributor.institutionInst Fed Educ Ciencia & Tecnol Maranhao
dc.contributor.institutionUniv Fed Piaui
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniv Fed Ceara
dc.date.accessioned2023-07-29T12:00:19Z
dc.date.available2023-07-29T12:00:19Z
dc.date.issued2023-04-13
dc.description.abstractToads of the Rhinella genus have a pair of paratoid glands that store biological secretions of high toxicity and varied chemical composition, rich in biologically active compounds. The present work aimed to carry out the investigation of the metabolomic profile and evaluation of the biological potential of the secretion paratoid glands (PGS) from Rhinella granulosa. The paratoid secretion was collected in the Piaui state (Brazil), extracted with methanol and the extract was analyzed by ultra-performance liquid chromatography with quadrupole time-of-flight mass spectrometry. Fifty chemical constituents were identified. The extract showed cytotoxicity against tumor cell lines of the central nervous system (half maximal inhibitory concentration (IC50) = 1.9 mu g mL-1) and prostate (IC50 = 1.6 mu g mL-1), unsatisfactory antimicrobial potential (minimal inhibitory concentration (MIC) > 312 mu g mL-1) and inhibited the enzyme acetylcholinesterase (IC50 = 5.119 mg mL-1). The results presented relevant information about the PGS and contributed to the understanding of the metabolomic and biological potential of R. granulosa.en
dc.description.affiliationInst Fed Educ Ciencia & Tecnol Maranhao, Dept Ensino Pesquisa & Extensao, BR-65620000 Coelho Neto, MA, Brazil
dc.description.affiliationUniv Fed Piaui, Dept Quim, Lab Prod Nat, BR-64049550 Teresina, PI, Brazil
dc.description.affiliationUniv Fed Piaui, Coordenacao Curso Ciencias Biol, BR-64607670 Picos, PI, Brazil
dc.description.affiliationUniv Fed Piaui, Lab Prod Nat & Neuroquim Expt, Nucleo Tecnol Farmaceut, BR-64049550 Teresina, PI, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Quim Organ, Inst Quim Araraquara, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Ceara, Lab Oncol Expt, Nucleo Pesquisa & Desenvolvimento Medicamentos, BR-60430275 Fortaleza, CE, Brazil
dc.description.affiliationInst Fed Educ Ciencia & Tecnol Maranhao, Dept Biol, BR-65030005 Sao Luis, MA, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Quim Organ, Inst Quim Araraquara, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipINCTBioNat
dc.description.sponsorshipCoordena��o de Aperfei�oamento de Pessoal de N�vel Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cient�fico e Tecnol�gico (CNPq)
dc.description.sponsorshipFAPEMA
dc.description.sponsorshipIdINCTBioNat: 465637/2014-0
dc.description.sponsorshipIdCAPES: 1776790/2017-0
dc.description.sponsorshipIdCNPq: 302197/2017-6
dc.description.sponsorshipIdCNPq: 402302/2021-4
dc.description.sponsorshipIdFAPEMA: 004348/2021
dc.format.extent12
dc.identifierhttp://dx.doi.org/10.21577/0103-5053.20230052
dc.identifier.citationJournal of the Brazilian Chemical Society. Sao Paulo: Soc Brasileira Quimica, 12 p., 2023.
dc.identifier.doi10.21577/0103-5053.20230052
dc.identifier.issn0103-5053
dc.identifier.urihttp://hdl.handle.net/11449/245621
dc.identifier.wosWOS:000972023400001
dc.language.isoeng
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofJournal Of The Brazilian Chemical Society
dc.sourceWeb of Science
dc.subjectRhinella granulosa
dc.subjecttoad secretion
dc.subjectUPLC-QToF-MS
dc.subjectMS
dc.subjectfingerprint
dc.subjectbiological activities
dc.titleUnraveling the Metabolomic Profile and Bioactivities of the Paratoid Gland Secretion from Rhinella granulosaen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Quimica

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