Gestational and lactational xenoestrogen exposure disrupts morphology and inflammatory aspects in mammary gland of gerbil mothers during involution

Ruiz, Thalles Fernando Rocha [UNESP]; Leonel, Ellen Cristina Rivas [UNESP]; Colleta, Simone Jacovaci [UNESP]; Bedolo, Carolina Marques [UNESP]; Pegorin de Campos, Silvana Gisele [UNESP]; Taboga, Sebastião Roberto [UNESP]

Gestational and lactational xenoestrogen exposure disrupts morphology and inflammatory aspects in mammary gland of gerbil mothers during involution

Data

2022-01-01

Autores

Ruiz, Thalles Fernando Rocha

Leonel, Ellen Cristina Rivas

Colleta, Simone Jacovaci

Bedolo, Carolina Marques

Pegorin de Campos, Silvana Gisele

Taboga, Sebastião Roberto

Tipo

Artigo

Resumo

In the mammary gland (MG), the developmental window for gestational/lactational differentiation and growth is highly vulnerable to hormonal disruption. Here we describe that the MG involution process in female gerbil mothers is delayed by bisphenol A (BPA) exposure during gestation and lactation. The process is directly influenced by changes in expression of extracellular matrix proteases MMP-2, MMP-9, and FAP, and the incidence of collagen and elastin is reduced after 7 and 14 days of weaning. A pro-inflammatory environment in the late involution process was confirmed by higher expression of TNF-α, COX-2 and phospho-STAT3 n the MG stroma, allied to increases in the incidence of macrophages and mast cells. These aspects impacted the proliferative pattern of epithelial cells, which decreased on the 14th post-weaning day. These data confirm that the milk production window of susceptibility is vulnerable to the impact of BPA, which promotes a suggestive pro-tumoral microenvironment during mammary involution.