Role of Yersinia pseudotuberculosis outer proteins (Yops) in murine humoral immune response
dc.contributor.author | Maia, J. M. L. [UNESP] | |
dc.contributor.author | Monnazzi, L. G. S. [UNESP] | |
dc.contributor.author | Medeiros, B. M. M. | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:24:11Z | |
dc.date.available | 2014-05-20T13:24:11Z | |
dc.date.issued | 2009-05-01 | |
dc.description.abstract | The infection of mice with the wild-type (WT) strain of Y. pseudotuberculosis did not induce polyclonal activation of B lymphocytes. Suppression in the production of certain isotypes of Ig was observed, provoked mainly by YopH, YopJ and YpkA. The WT strain induced a progressive increase in the serum-specific IgG, which peaked after 4 weeks after infection, IgM being produced only after 1 week. Autoantibodies against phosphorylcholine, myelin, thyroglobulin and cardiolipin could be detected in the serum of mice infected with the WT strain. The infection of mice provoked suppression in the production of immunoglobulins by splenic B cells and that YopH, YopJ and YpkA must be involved here. | en |
dc.description.affiliation | São Paulo State Univ, Sch Pharmaceut Sci, Dept Biol Sci, Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | São Paulo State Univ, Sch Pharmaceut Sci, Dept Biol Sci, Araraquara, SP, Brazil | |
dc.description.sponsorship | Programa de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC) | |
dc.description.sponsorship | Coordena ao de Aperfei oamento de Pessoal de Nivel Superior, Brazil | |
dc.description.sponsorshipId | PADC: PADC 2004/6-I | |
dc.format.extent | 239-245 | |
dc.identifier | http://dx.doi.org/10.1007/s12223-009-0038-1 | |
dc.identifier.citation | Folia Microbiologica. Dordrecht: Springer, v. 54, n. 3, p. 239-245, 2009. | |
dc.identifier.doi | 10.1007/s12223-009-0038-1 | |
dc.identifier.issn | 0015-5632 | |
dc.identifier.uri | http://hdl.handle.net/11449/7435 | |
dc.identifier.wos | WOS:000268573600011 | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation.ispartof | Folia Microbiologica | |
dc.relation.ispartofjcr | 1.311 | |
dc.relation.ispartofsjr | 0,502 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | Role of Yersinia pseudotuberculosis outer proteins (Yops) in murine humoral immune response | en |
dc.type | Artigo | |
dcterms.license | http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0 | |
dcterms.rightsHolder | Springer | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Ciências Biológicas - FCF | pt |
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