Leishmanicidal activity of biogenic Fe3O4 nanoparticles

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dc.contributor.authorKhatami, Mehrdad
dc.contributor.authorAlijani, Hajar
dc.contributor.authorSharifi, Iraj
dc.contributor.authorSharifi, Fatemeh
dc.contributor.authorPourseyedi, Shahram
dc.contributor.authorKharazi, Sam
dc.contributor.authorNobre, Marcos Augusto Lima [UNESP]
dc.contributor.authorKhatami, Manouchehr
dc.contributor.institutionBam University of Medical Sciences
dc.contributor.institutionShiraz University of Medical Sciences
dc.contributor.institutionKerman University of Medical Sciences
dc.contributor.institutionShahid Bahonar University of Kerman
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:50:42Z
dc.date.available2018-12-11T16:50:42Z
dc.date.issued2017-12-01
dc.description.abstractDue to the multiplicity of useful applications of metal oxide nanoparticles (ONPs) in medicine are growing exponentially, in this study, Fe3O4 (iron oxide) nanoparticles (IONPs) were biosynthesized using Rosemary to evaluate the leishmanicidal efficiency of green synthesized IONPs. This is the first report of the leishmanicidal efficiency of green synthesized IONPs against Leishmania major. The resulting biosynthesized IONPs were characterized by ultraviolet-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR). The leishmanicidal activity of IONPS was studied via 3-4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The results showed the fabrication of the spherical shape of monodisperse IONPs with a size 4 ± 2 nm. The UV-visible spectrophotometer absorption peak was at 334 nm. The leishmanicidal activity of biogenic iron oxide nanoparticles against Leishmania major (promastigote) was also studied. The IC50 of IONPs was 350 μg/mL. In this report, IONPs were synthesized via a green method. IONPs are mainly spherical and homogeneous, with an average size of about 4 nm, and were synthesized here using an eco-friendly, simple, and inexpensive method.en
dc.description.affiliationSchool of Medicine Bam University of Medical Sciences
dc.description.affiliationNanomedicine and Nanobiology Research Center Shiraz University of Medical Sciences
dc.description.affiliationLeishmaniasis Research Center Kerman University of Medical Sciences
dc.description.affiliationPharmaceutics Research Center Institute of Neuropharmacology Kerman University of Medical Sciences
dc.description.affiliationDepartment of Biotechnology Shahid Bahonar University of Kerman
dc.description.affiliationFac de Ciências e Tecnologia-FCT Universidade Estadual Paulista-UNESP
dc.description.affiliationDepartment of Radiology Kerman University of Medical Sciences
dc.description.affiliationUnespFac de Ciências e Tecnologia-FCT Universidade Estadual Paulista-UNESP
dc.description.sponsorshipShiraz University of Medical Sciences
dc.description.sponsorshipIdShiraz University of Medical Sciences: 15643
dc.identifierhttp://dx.doi.org/10.3390/scipharm85040036
dc.identifier.citationScientia Pharmaceutica, v. 85, n. 4, 2017.
dc.identifier.doi10.3390/scipharm85040036
dc.identifier.issn2218-0532
dc.identifier.issn0036-8709
dc.identifier.lattes7201928600704530
dc.identifier.scopus2-s2.0-85035025085
dc.identifier.urihttp://hdl.handle.net/11449/170417
dc.language.isoeng
dc.relation.ispartofScientia Pharmaceutica
dc.relation.ispartofsjr0,268
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBiosynthesis
dc.subjectIONPs
dc.subjectIron oxide nanoparticles
dc.subjectLeishmanicidal
dc.titleLeishmanicidal activity of biogenic Fe3O4 nanoparticlesen
dc.typeArtigo
unesp.author.lattes7201928600704530

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