Histological investigation of a 10% metronidazole and 2% lidocaine dressing on wound healing in rats.

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dc.contributor.authorRodrigues, T. S.
dc.contributor.authorPoi, Wilson Roberto [UNESP]
dc.contributor.authorBarioni, Sônia Regina Panzarini [UNESP]
dc.contributor.authorBezerra, C. S.
dc.contributor.authorSilva, J. L.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:02Z
dc.date.available2014-05-27T11:22:02Z
dc.date.issued2006-11-01
dc.description.abstractAIM: Alveolitis is considered a disturbance of the alveolar healing process that is characterized by blood clot disintegration, alveolar wall infection and extreme pain. Several substances have been investigated to improve healing and guarantee postoperative comfort to patients. The aim of this study was to evaluate, microscopically, in rats, the healing process in non-infected tooth sockets, after application of a 10% metronidazole and 2% lidocaine dressing, using lanolin as vehicle and mint as flavoring. METHODS: Forty-five rats (Rattus norvegicus albinus, Wistar) had their right incisor extracted and were randomly assigned to 3 groups (n=15): Group I (control): the sockets were filled with blood clot; Group II: application of adrenaline solution at 1:1 000 with an absorbent paper point during 1 min plus filling of the socket with a 10% metronidazole and 2% lidocaine dressing, with lanolin as vehicle, and mint as flavoring; Group III: filling of the socket with the 10% metronidazole and 2% lidocaine dressing, with lanolin as vehicle and mint as flavoring. After 6, 15 and 28 days postoperatively, 5 animals per group were euthanized with an injectable anesthetic overdose. Histological and statistical analyses were performed. RESULTS: The results showed that the 10% metronidazole and 2% lidocaine dressing with lanolin as vehicle and mint as flavoring yielded similar response as that of the normal repair group and may be used to prevent the onset of alveolitis in those cases in which any predisposing factor is present. CONCLUSIONS: The use of this dressing has shown a good postoperative patient's comfort and does not cause a significant delay in the alveolar healing process.en
dc.format.extent619-626
dc.identifierhttp://www.minervamedica.it/en/journals/minerva-stomatologica/article.php?cod=R18Y2006N11A0619
dc.identifier.citationMinerva stomatologica, v. 55, n. 11-12, p. 619-626, 2006.
dc.identifier.issn0026-4970
dc.identifier.lattes4185776888167996
dc.identifier.lattes5691730284259344
dc.identifier.scopus2-s2.0-34347204174
dc.identifier.urihttp://hdl.handle.net/11449/69217
dc.language.isoeng
dc.relation.ispartofMinerva stomatologica
dc.relation.ispartofsjr0,301
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectlidocaine
dc.subjectmetronidazole
dc.subjectanimal
dc.subjectdrug combination
dc.subjectdrug effect
dc.subjectevaluation
dc.subjecthistology
dc.subjectmale
dc.subjectperiodontic device
dc.subjectphysiology
dc.subjectrat
dc.subjecttooth socket
dc.subjectWistar rat
dc.subjectwound healing
dc.subjectAnimals
dc.subjectDrug Therapy, Combination
dc.subjectLidocaine
dc.subjectMale
dc.subjectMetronidazole
dc.subjectPeriodontal Dressings
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTooth Socket
dc.subjectWound Healing
dc.titleHistological investigation of a 10% metronidazole and 2% lidocaine dressing on wound healing in rats.en
dc.typeArtigo
unesp.author.lattes4185776888167996
unesp.author.lattes5691730284259344
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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