Current advances in antitubercular drug discovery: potent prototypes and new targets

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dc.contributor.authorFernandes, Guilherme Felipe dos Santos [UNESP]
dc.contributor.authorJornada, Daniela Hartmann [UNESP]
dc.contributor.authorSouza, Paula Carolina de [UNESP]
dc.contributor.authorChin, Chung Man [UNESP]
dc.contributor.authorPavan, Fernando Rogerio [UNESP]
dc.contributor.authorSantos, Jean Leandro dos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:35:53Z
dc.date.available2015-12-07T15:35:53Z
dc.date.issued2015
dc.description.abstractTuberculosis (TB) is an infectious disease caused by bacterium of the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization aims to substantially reduce the number of cases in the coming years; however, the increased number of multidrug-resistant (MDR) and extremely drug-resistant (XDR) forms of the bacterium and the lack of treatment for latent tuberculosis are challenges to be overcome. In this review, we have identified the most potent compounds described in the literature during recent years with MIC values < 7 µM, low toxicity and a high selective index. In addition, emerging targets in MTB are presented to provide new perspectives for the discovery of new antitubercular drugs. This review aims to summarize the current advances in and promote insights into antitubercular drug discovery.en
dc.description.affiliationSchool of Pharmaceutical Sciences, State University of São Paulo, Zipcode: 14801- 902, Araraquara, Brazil.
dc.description.affiliationUnespSchool of Pharmaceutical Sciences, State University of São Paulo, Zipcode: 14801- 902, Araraquara, Brazil.
dc.format.extent3133-3161
dc.identifierhttp://dx.doi.org/10.2174/0929867322666150818103836#sthash.EOREFJmy.dpuf
dc.identifier.citationCurrent Medicinal Chemistry, v. 22, n. 27, p. 3133-3161, 2015.
dc.identifier.doi10.2174/0929867322666150818103836#sthash.EOREFJmy.dpuf
dc.identifier.issn1875-533X
dc.identifier.lattes9734333607975413
dc.identifier.orcid0000-0003-4141-0455
dc.identifier.pubmed26282941
dc.identifier.urihttp://hdl.handle.net/11449/131461
dc.language.isoeng
dc.publisherBentham Science Publishers
dc.relation.ispartofCurrent Medicinal Chemistry
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectAntitubercular drugsen
dc.subjectDrug discoveryen
dc.subjectMycobacterium tuberculosisen
dc.subjectResistant tuberculosisen
dc.subjectTuberculosisen
dc.subjectTuberculosis targetsen
dc.titleCurrent advances in antitubercular drug discovery: potent prototypes and new targetsen
dc.typeArtigo
dcterms.rightsHolderBentham Science Publishers
unesp.author.lattes9734333607975413[4]
unesp.author.orcid0000-0003-4141-0455[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas