Mu and kappa opioid receptors of the periaqueductal gray stimulate and inhibit thermogenesis, respectively, during psychological stress in rats

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dc.contributor.authorCristina-Silva, Caroline [UNESP]
dc.contributor.authorMartins, Victor [UNESP]
dc.contributor.authorGargaglioni, Luciane H. [UNESP]
dc.contributor.authorBicego, Kenia C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNatl Inst Sci & Technol Comparat Physiol INCT Fis
dc.date.accessioned2018-11-26T17:40:15Z
dc.date.available2018-11-26T17:40:15Z
dc.date.issued2017-09-01
dc.description.abstractThe periaqueductal gray matter (PAG) is rich in mu and kappa opioid receptors, and this system is involved in thermoregulation, analgesia, and defensive behaviors. No study approached the involvement of the PAG opioids in body temperature (Tb) regulation during psychological stress such as restraint. Because activation of mu and kappa receptors increases and reduces Tb, respectively, we tested the hypothesis that they exert excitatory and inhibitory modulation, respectively, of the restraint-induced fever in rats. To this end, Tb, heat loss index (HLI, inference for peripheral vasoconstriction/vasodilation), and oxygen consumption (inference for thermogenesis) were monitored in unanesthetized rats, restrained or unrestrained, before and after intra-PAG microinjection of the selective mu opioid receptor antagonist (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 cyclic, CTAP; 1 and 10 mu g/100 nL) or the selective kappa opioid receptor antagonist (nor-binaltorphimine dihydrochloride, nor-BNI; 1 and 4 mu g/100 nL) or saline (100 nL). CTAP and nor-BNI did not change the Tb or HLI of euthermic animals. During restraint, Tb increased (1.0 +/- 0.1 A degrees C) in all groups; however, this effect was lower in those animals treated with CTAP and higher in animals treated with nor-BNI. The HLI decreased during restraint and increased after animals were released, but this response was not affected by any treatment. Restraint stress increased oxygen consumption (35.9 +/- 3.9% elevation), but this response was diminished by CTAP and overstimulated by nor-BNI. Confirming our hypothesis, the results indicate that the mu and kappa opioid receptors in the PAG of rats play a pyrogenic and antipyretic role, respectively, during fever induced by restraint by affecting the thermogenic but not the heat conservation effector.en
dc.description.affiliationSao Paulo State Univ, Dept Anim Morphol & Physiol, Coll Agr & Vet Sci, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationNatl Inst Sci & Technol Comparat Physiol INCT Fis, Jaboticabal, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Morfol & Fisiol Anim, Fac Ciencias Agr & Vet, Via Acesso Paulo Donato Castellane S-N, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Anim Morphol & Physiol, Coll Agr & Vet Sci, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Morfol & Fisiol Anim, Fac Ciencias Agr & Vet, Via Acesso Paulo Donato Castellane S-N, BR-14884900 Jaboticabal, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2013/02813-9
dc.description.sponsorshipIdFAPESP: 2015/04849-6
dc.format.extent1151-1161
dc.identifierhttp://dx.doi.org/10.1007/s00424-017-1966-2
dc.identifier.citationPflugers Archiv-european Journal Of Physiology. New York: Springer, v. 469, n. 9, p. 1151-1161, 2017.
dc.identifier.doi10.1007/s00424-017-1966-2
dc.identifier.fileWOS000407627800010.pdf
dc.identifier.issn0031-6768
dc.identifier.urihttp://hdl.handle.net/11449/163136
dc.identifier.wosWOS:000407627800010
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofPflugers Archiv-european Journal Of Physiology
dc.relation.ispartofsjr1,479
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBody temperature
dc.subjectHeat loss index
dc.subjectOxygen consumption
dc.subjectOpioid receptors
dc.subjectNor-BNI
dc.subjectCTAP
dc.titleMu and kappa opioid receptors of the periaqueductal gray stimulate and inhibit thermogenesis, respectively, during psychological stress in ratsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.departmentMorfologia e Fisiologia Animal - FCAVpt

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