Serum myeloperoxidase level is Increased in heavy smokers

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dc.contributor.authorMartins, Anfrá B. [UNESP]
dc.contributor.authorXimenes, Valdecir Farias [UNESP]
dc.contributor.authorFonseca, Luiz Marcos da [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:56:17Z
dc.date.available2016-01-28T16:56:17Z
dc.date.issued2013
dc.description.abstractRaised myeloperoxidase (MPO) serum levels are associated with endothelial dysfunction and cigarette smoking is a risk factor for cardiovascular diseases. Since myocardial infarction is associated with leukocytosis and smokers present increased levels of neutrophils, here we hypothesized that the levels of serum MPO in smokers could be also raised. We carried out a study on sixty eight adult healthy volunteers. The control group consisted of thirty four non-smokers and the test group was thirty four heavy smokers. The hemogram, interleukin-8 (IL-8) and MPO serum levels were measured. Neutrophil, monocyte and lymphocyte counts were higher (p < 0.05) and the serum levels of interleukin-8 (IL-8) and MPO were fourfold higher in smokers than in non-smokers (n = 34, p < 0.05). This result correlated perfectly with the increased neutrophil count and IL-8 serum level that characterize smoking subjects. We propose that the high level of serum MPO could be directly involved in the higher prevalence of coronary artery diseases among heavy smokers.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Araçatuba, SP, Brasil
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química, Faculdade de Ciências, UNESP/Campus de Bauru, Bauru, Av Eng Luiz Edmundo Carrijo Coube, S/N, Vargem Limpa, CEP 17033360, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Araçatuba, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química, Faculdade de Ciências, UNESP/Campus de Bauru, Bauru, Av Eng Luiz Edmundo Carrijo Coube, S/N, Vargem Limpa, CEP 17033360, SP, Brasil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent5-8
dc.identifierhttp://dx.doi.org/10.4236/ojcd.2013.31002
dc.identifier.citationOpen Journal of Clinical Diagnostics, v. 3, n. 1, p. 5-8, 2013.
dc.identifier.doi10.4236/ojcd.2013.31002
dc.identifier.issn2162-5816
dc.identifier.lattes4419635633356792
dc.identifier.lattes4066413997908572
dc.identifier.urihttp://hdl.handle.net/11449/133715
dc.language.isoeng
dc.relation.ispartofOpen Journal of Clinical Diagnostics
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectSmokersen
dc.subjectNeutrophilsen
dc.subjectIL-8en
dc.subjectMyeloperoxidaseen
dc.subjectHypochlorous aciden
dc.subjectAtherosclerosisen
dc.titleSerum myeloperoxidase level is Increased in heavy smokersen
dc.typeArtigo
unesp.author.lattes4419635633356792
unesp.author.lattes4066413997908572
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências, Baurupt
unesp.departmentAnálises Clínicaspt
unesp.departmentQuímica - FCpt

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Artigos - Análises Clínicas - FCFAR
Bauru - FC - Faculdade de Ciências