Use of Photodynamic Therapy Associated with Antimicrobial Peptides for Bacterial Control: A Systematic Review and Meta-Analysis
dc.contributor.author | Dias, Luana Mendonça [UNESP] | |
dc.contributor.author | Ferrisse, Túlio Morandin [UNESP] | |
dc.contributor.author | Medeiros, Karine Sousa [UNESP] | |
dc.contributor.author | Cilli, Eduardo Maffud [UNESP] | |
dc.contributor.author | Pavarina, Ana Claudia [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.date.accessioned | 2022-04-29T08:41:16Z | |
dc.date.available | 2022-04-29T08:41:16Z | |
dc.date.issued | 2022-03-01 | |
dc.description.abstract | Considering the challenges related to antimicrobial resistance, other strategies for controlling infections have been suggested, such as antimicrobial photodynamic therapy (aPDT) and antimicrobial peptides (AMP). This study aims to perform a systematic review and meta-analysis to obtain evidence on the antimicrobial effectiveness of aPDT associated with AMP and establish in vitro knowledge on this topic for further study designs. The PubMed, Scopus, Web of Science, Science Direct, Scielo, and Cochrane Library databases were searched. Two independent and cal-ibrated researchers (Kappa = 0.88) performed all the systematic steps according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The odds ratio (OR) was used as the effect measure. The Peto method was used to perform the meta-analysis due to the sparse data. Twenty studies were included in the present review. The result was significant (OR = 0.14/ p = 0.0235/I-squared = 0%), showing better outcomes of aPDT associated with peptides than those of aPDT alone for controlling the microbial load. Only 20% of the studies included evaluated this approach in a biofilm culture. Combined treatment with aPDT and AMP highly increased the ability of microbial reduction of Gram-positive and Gram-negative bacteria. However, additional blind studies are required to evaluate the efficacy of this therapy on microbial biofilms. | en |
dc.description.affiliation | Laboratory of Applied Microbiology Department of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP) | |
dc.description.affiliation | Department of Biochemistry and Organic Chemistry Institute of Chemistry São Paulo State University (UNESP) | |
dc.description.affiliationUnesp | Laboratory of Applied Microbiology Department of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP) | |
dc.description.affiliationUnesp | Department of Biochemistry and Organic Chemistry Institute of Chemistry São Paulo State University (UNESP) | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorshipId | FAPESP: 2013/07276-1 | |
dc.description.sponsorshipId | FAPESP: 2020/16227-8 | |
dc.description.sponsorshipId | FAPESP: 2021/01191-0 | |
dc.description.sponsorshipId | FAPESP: 2021/06476-3 | |
dc.identifier | http://dx.doi.org/10.3390/ijms23063226 | |
dc.identifier.citation | International Journal of Molecular Sciences, v. 23, n. 6, 2022. | |
dc.identifier.doi | 10.3390/ijms23063226 | |
dc.identifier.issn | 1422-0067 | |
dc.identifier.issn | 1661-6596 | |
dc.identifier.scopus | 2-s2.0-85126897745 | |
dc.identifier.uri | http://hdl.handle.net/11449/230624 | |
dc.language.iso | eng | |
dc.relation.ispartof | International Journal of Molecular Sciences | |
dc.source | Scopus | |
dc.subject | Anti-infective agents | |
dc.subject | Antimicrobial peptides | |
dc.subject | Photochemotherapy | |
dc.title | Use of Photodynamic Therapy Associated with Antimicrobial Peptides for Bacterial Control: A Systematic Review and Meta-Analysis | en |
dc.type | Resenha | |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Química, Araraquara | pt |
unesp.department | Bioquímica e Tecnologia - IQ | pt |