Use of Photodynamic Therapy Associated with Antimicrobial Peptides for Bacterial Control: A Systematic Review and Meta-Analysis

dc.contributor.authorDias, Luana Mendonça [UNESP]
dc.contributor.authorFerrisse, Túlio Morandin [UNESP]
dc.contributor.authorMedeiros, Karine Sousa [UNESP]
dc.contributor.authorCilli, Eduardo Maffud [UNESP]
dc.contributor.authorPavarina, Ana Claudia [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:41:16Z
dc.date.available2022-04-29T08:41:16Z
dc.date.issued2022-03-01
dc.description.abstractConsidering the challenges related to antimicrobial resistance, other strategies for controlling infections have been suggested, such as antimicrobial photodynamic therapy (aPDT) and antimicrobial peptides (AMP). This study aims to perform a systematic review and meta-analysis to obtain evidence on the antimicrobial effectiveness of aPDT associated with AMP and establish in vitro knowledge on this topic for further study designs. The PubMed, Scopus, Web of Science, Science Direct, Scielo, and Cochrane Library databases were searched. Two independent and cal-ibrated researchers (Kappa = 0.88) performed all the systematic steps according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The odds ratio (OR) was used as the effect measure. The Peto method was used to perform the meta-analysis due to the sparse data. Twenty studies were included in the present review. The result was significant (OR = 0.14/ p = 0.0235/I-squared = 0%), showing better outcomes of aPDT associated with peptides than those of aPDT alone for controlling the microbial load. Only 20% of the studies included evaluated this approach in a biofilm culture. Combined treatment with aPDT and AMP highly increased the ability of microbial reduction of Gram-positive and Gram-negative bacteria. However, additional blind studies are required to evaluate the efficacy of this therapy on microbial biofilms.en
dc.description.affiliationLaboratory of Applied Microbiology Department of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationDepartment of Biochemistry and Organic Chemistry Institute of Chemistry São Paulo State University (UNESP)
dc.description.affiliationUnespLaboratory of Applied Microbiology Department of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Biochemistry and Organic Chemistry Institute of Chemistry São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2013/07276-1
dc.description.sponsorshipIdFAPESP: 2020/16227-8
dc.description.sponsorshipIdFAPESP: 2021/01191-0
dc.description.sponsorshipIdFAPESP: 2021/06476-3
dc.identifierhttp://dx.doi.org/10.3390/ijms23063226
dc.identifier.citationInternational Journal of Molecular Sciences, v. 23, n. 6, 2022.
dc.identifier.doi10.3390/ijms23063226
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.scopus2-s2.0-85126897745
dc.identifier.urihttp://hdl.handle.net/11449/230624
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.sourceScopus
dc.subjectAnti-infective agents
dc.subjectAntimicrobial peptides
dc.subjectPhotochemotherapy
dc.titleUse of Photodynamic Therapy Associated with Antimicrobial Peptides for Bacterial Control: A Systematic Review and Meta-Analysisen
dc.typeResenha
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.departmentBioquímica e Tecnologia - IQpt

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