Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis

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dc.contributor.authorHerculano, Rondinelli Donizetti [UNESP]
dc.contributor.authordos Santos, Thainá Oliveira [UNESP]
dc.contributor.authorde Barros, Natan Roberto
dc.contributor.authorPegorin Brasil, Giovana Sant'Ana [UNESP]
dc.contributor.authorScontri, Mateus [UNESP]
dc.contributor.authorCarvalho, Bruna Gregatti
dc.contributor.authorMecwan, Marvin
dc.contributor.authorFarhadi, Neda
dc.contributor.authorKawakita, Satoru
dc.contributor.authorPerego, Caio Humberto [UNESP]
dc.contributor.authorCarvalho, Flávio Alexandre [UNESP]
dc.contributor.authordos Santos, André Gonzaga [UNESP]
dc.contributor.authorGuerra, Nayrim Brizuela
dc.contributor.authorFloriano, Juliana Ferreira [UNESP]
dc.contributor.authorMussagy, Cassamo Ussemane
dc.contributor.authorTirpáková, Zuzana
dc.contributor.authorKhorsandi, Danial
dc.contributor.authorPeirsman, Arne
dc.contributor.authorNguyen, Huu Tuan
dc.contributor.authorGomez, Alejandro
dc.contributor.authorMandal, Kalpana
dc.contributor.authorde Mendonça, Ricardo José
dc.contributor.authorLi, Bingbing
dc.contributor.authorDokmeci, Mehmet Remzi
dc.contributor.authorJucaud, Vadim
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionTerasaki Institute for Biomedical Innovation (TIBI)
dc.contributor.institutionCalifornia State University
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversity of Caxias do Sul (UCS)
dc.contributor.institutionPontificia Universidad Católica de Valparaíso
dc.contributor.institutionThe University of Veterinary Medicine and Pharmacy in Košice
dc.contributor.institutionReconstructive and Aesthetic Surgery University Hospital Ghent
dc.contributor.institutionFederal University of Triangulo Mineiro (UFTM)
dc.date.accessioned2023-07-29T16:13:16Z
dc.date.available2023-07-29T16:13:16Z
dc.date.issued2023-07-01
dc.description.abstractPsoriasis is a disease that causes keratinocytes to proliferate ten times faster than normal, resulting in chronic inflammation and immune cell infiltration in the skin. Aloe vera (A. vera) creams have been used topically for treating psoriasis because they contain several antioxidant species; however, they have several limitations. Natural rubber latex (NRL) has been used as occlusive dressings to promote wound healing by stimulating cell proliferation, neoangiogenesis, and extracellular matrix formation. In this work, we developed a new A. vera-releasing NRL dressing by a solvent casting method to load A. vera into NRL. FTIR and rheological analyzes revealed no covalent interactions between A. vera and NRL in the dressing. We observed that 58.8 % of the loaded A. vera, present on the surface and inside the dressing, was released after 4 days. Biocompatibility and hemocompatibility were validated in vitro using human dermal fibroblasts and sheep blood, respectively. We observed that ~70 % of the free antioxidant properties of A. vera were preserved, and the total phenolic content was 2.31-fold higher than NRL alone. In summary, we combined the antipsoriatic properties of A. vera with the healing activity of NRL to generate a novel occlusive dressing that may be indicated for the management and/or treatment of psoriasis symptoms simply and economically.en
dc.description.affiliationSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences, SP
dc.description.affiliationTerasaki Institute for Biomedical Innovation (TIBI), 11507 W Olympic Blvd
dc.description.affiliationAutonomy Research Center for STEAHM (ARCS) California State University
dc.description.affiliationSão Paulo State University (UNESP) Post-Graduate Program in Biotechnology Institute of Chemistry, SP
dc.description.affiliationUniversity of Campinas (UNICAMP) Department of Materials and Bioprocesses Engineering School of Chemical Engineering, SP
dc.description.affiliationSão Paulo State University (UNESP) Pharmacognosy Laboratory School of Pharmaceutical Sciences, SP
dc.description.affiliationArea of Exact Sciences and Engineering University of Caxias do Sul (UCS), RS
dc.description.affiliationEscuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de Valparaíso
dc.description.affiliationThe University of Veterinary Medicine and Pharmacy in Košice, Komenského
dc.description.affiliationPlastic Reconstructive and Aesthetic Surgery University Hospital Ghent
dc.description.affiliationDepartment of Biochemistry Pharmacology and Physiology Federal University of Triangulo Mineiro (UFTM), MG
dc.description.affiliationUnespSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences, SP
dc.description.affiliationUnespSão Paulo State University (UNESP) Post-Graduate Program in Biotechnology Institute of Chemistry, SP
dc.description.affiliationUnespSão Paulo State University (UNESP) Pharmacognosy Laboratory School of Pharmaceutical Sciences, SP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2017/19603-8
dc.description.sponsorshipIdFAPESP: 2018/07342-8
dc.description.sponsorshipIdFAPESP: 2021/09207-3
dc.description.sponsorshipIdCNPq: 317203/2021-5
dc.description.sponsorshipIdCNPq: 401285/2022-7
dc.description.sponsorshipIdCNPq: 470261/2012-9
dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2023.124779
dc.identifier.citationInternational Journal of Biological Macromolecules, v. 242.
dc.identifier.doi10.1016/j.ijbiomac.2023.124779
dc.identifier.issn1879-0003
dc.identifier.issn0141-8130
dc.identifier.scopus2-s2.0-85158892748
dc.identifier.urihttp://hdl.handle.net/11449/249937
dc.language.isoeng
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.sourceScopus
dc.subjectAloe vera
dc.subjectComplementary treatment
dc.subjectNatural rubber latex
dc.subjectOcclusive dressing
dc.subjectPsoriasis
dc.titleAloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasisen
dc.typeArtigo
unesp.departmentCiências Biológicas - FCLASpt

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