Evaluation of the presence of VEGF, BMP2 and CBFA1 proteins in autogenous bone graft: Histometric and immunohistochemical analysis

Página do item simplificado
dc.contributor.authorGuskuma, Marcos Heidy
dc.contributor.authorVieira, Eduardo Hochuli [UNESP]
dc.contributor.authorPereira, Flávia Priscila
dc.contributor.authorRangel-Garcia Jr., Idelmo
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.contributor.authorOkamoto, Tetuo
dc.contributor.authorFilho, Osvaldo Magro
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:08Z
dc.date.available2014-05-27T11:30:08Z
dc.date.issued2013-08-08
dc.description.abstractAims: The purpose of this study was to evaluate the expression of proteins that participate in the osteoinduction stage (VEGF, BMP2 and CBFA1) of the process of bone regeneration of defects created in rat calvariae and filled with autogenous bone block grafts. Materials and methods: 10 adult male rats (Rattus norvegicus albinus, Wistar) were used, who received two bone defects measuring 5 mm each in the calvariae. The bone defects constituted two experimental groups (n = 10): Control Group (CONT) (defects filled with a coagulum); Graft Group (GR) (defects filled with autogenous bone removed from the contralateral defect). The animals were submitted to euthanasia at 7 and 30 days post-operatively. Results: Quantitative analysis demonstrated significantly greater bone formation in Group GR, but the presence of the studied proteins was significantly greater in the CONT Group in both time intervals of observation. Conclusion: It was not possible in this study in cortical bone block groups to detect the osteoinductive proteins in a significant amount during the repair process. © 2013 European Association for Cranio-Maxillo-Facial Surgery.en
dc.identifierhttp://dx.doi.org/10.1016/j.jcms.2013.05.022
dc.identifier.citationJournal of Cranio-Maxillofacial Surgery.
dc.identifier.doi10.1016/j.jcms.2013.05.022
dc.identifier.issn1010-5182
dc.identifier.issn1878-4119
dc.identifier.lattes1566928219828056
dc.identifier.lattes0169955363968097
dc.identifier.scopus2-s2.0-84880993048
dc.identifier.urihttp://hdl.handle.net/11449/76239
dc.identifier.wosWOS:000336703100010
dc.language.isoeng
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgery
dc.relation.ispartofjcr1.960
dc.relation.ispartofsjr1,033
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBone Morphogenetic Protein 2
dc.subjectBone transplant
dc.subjectCore Binding Factor Alpha 1 Subunit
dc.subjectImmunohistochemistry
dc.subjectVascular Endothelial Growth Factor A
dc.titleEvaluation of the presence of VEGF, BMP2 and CBFA1 proteins in autogenous bone graft: Histometric and immunohistochemical analysisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes6853485483683678[2]
unesp.author.orcid0000-0003-4040-9313[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

Arquivos

Coleções

Artigos - Diagnóstico e Cirurgia - FOAR
Artigos - Cirurgia e Clínica Integrada - FOA
Artigos - Ciências Básicas - FOA