Metastatic melanoma of the tongue: a case report with immunohistochemical profile

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dc.contributor.authorAlves, Monica Ghislaine O. [UNESP]
dc.contributor.authorChagas, Luciene R.
dc.contributor.authorCarvalho, Yasmin R. [UNESP]
dc.contributor.authorCabral, Luiz A. G. [UNESP]
dc.contributor.authorColetta, Ricardo D.
dc.contributor.authorAlmeida, Janete D. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Vale Paraiba
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2015-03-18T15:55:13Z
dc.date.available2015-03-18T15:55:13Z
dc.date.issued2014-12-01
dc.description.abstractBackgroundMelanoma of the skin is characterised by a high metastatic potential, but reports of metastasis to the tongue are rare. We report a case of skin melanoma with metastasis to the lymph nodes, tongue and brain.ObjectivesThis report highlights the clinical and histological features of oral metastatic melanoma.Case reportA 72-year-old man was seen with a nodule on the tongue. The differential diagnosis included salivary gland tumour, lymphoma and metastatic melanoma. His medical history revealed treatment for melanoma in the periumbilical region and micrometastases in the inguinal lymph nodes. An incisional biopsy was obtained and histological analysis showed the presence of a solid, epithelioid malignant tumour of monotonous appearance infiltrating the skeletal musculature. Immunohistochemistry showed reactivity of neoplastic cells to anti-HMB45, anti-melan A and anti-S100 antibodies and negativity for anti-PAN cytokeratin, confirming the diagnosis of metastatic melanoma.ConclusionThe present findings highlight the importance of a complete medical evaluation of the patient by anamnesis to identify possible oral repercussions of primary diseases in other organs and/or systems.en
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Biosci & Oral Diag, Sao Jose dos Campos Dent Sch, Sao Paulo, Brazil
dc.description.affiliationUniv Vale Paraiba, Sch Hlth Sci, Nursing Course, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Piracicaba Dent Sch, Oral Pathol Div, Dept Oral Diag, Sao Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Biosci & Oral Diag, Sao Jose dos Campos Dent Sch, Sao Paulo, Brazil
dc.format.extent314-319
dc.identifierhttp://dx.doi.org/10.1111/ger.12032
dc.identifier.citationGerodontology. Hoboken: Wiley-blackwell, v. 31, n. 4, p. 314-319, 2014.
dc.identifier.doi10.1111/ger.12032
dc.identifier.issn0734-0664
dc.identifier.urihttp://hdl.handle.net/11449/117111
dc.identifier.wosWOS:000345633200012
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofGerodontology
dc.relation.ispartofjcr1.439
dc.relation.ispartofsjr0,627
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectoral mucosaen
dc.subjectmelanomaen
dc.subjectoral canceren
dc.subjectskin canceren
dc.subjectimmunohistochemistryen
dc.titleMetastatic melanoma of the tongue: a case report with immunohistochemical profileen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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