Colloidal carriers for ophthalmic drug delivery

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dc.contributor.authorMainardes, R. M.
dc.contributor.authorUrban, MCC
dc.contributor.authorCinto, P. O.
dc.contributor.authorKhalil, N. M.
dc.contributor.authorChaud, M. V.
dc.contributor.authorEvangelista, Raul Cesar [UNESP]
dc.contributor.authorGremiao, MPD
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUNIMEP
dc.date.accessioned2014-05-20T13:24:39Z
dc.date.available2014-05-20T13:24:39Z
dc.date.issued2005-05-01
dc.description.abstractTo achieve effective drug concentration at the intended site for a sufficient period of time is a requisite desired for many drug formulations. For drugs intended to ocular delivery, its poor bioavailability is due to pre-corneal factors. Most ocular diseases are treated by topical drug application in the form of solution, suspension and ointment. However, such dosage forms are no longer sufficient to combat some ocular diseases. Intravitreal drug injection is the current therapy for disorders in posterior segment. The procedure is associated with a high risk of complications, particularly when frequent, repeated injections are required. Thus, sustained-release technologies are being proposed, and the benefits of using colloidal carriers in intravitreal injections are currently under investigation for posterior drug delivery. This review will discuss recent progress and specific development issues relating to colloidal drug delivery systems, such as liposomes, niosomes, nanoparticles, and microemulsions in ocular drug delivery.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, Lab Tecnol Farmaceut, BR-14806192 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Dept Farmacos & Medicaments, BR-14806192 Araraquara, SP, Brazil
dc.description.affiliationUNIMEP, Dept Ciências Saude, Piracicaba, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, Lab Tecnol Farmaceut, BR-14806192 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Farmacos & Medicaments, BR-14806192 Araraquara, SP, Brazil
dc.format.extent363-371
dc.identifierhttp://dx.doi.org/10.2174/1389450053765914
dc.identifier.citationCurrent Drug Targets. Sharjah: Bentham Science Publ Ltd, v. 6, n. 3, p. 363-371, 2005.
dc.identifier.doi10.2174/1389450053765914
dc.identifier.issn1389-4501
dc.identifier.lattes5361569184579557
dc.identifier.urihttp://hdl.handle.net/11449/7714
dc.identifier.wosWOS:000228824900010
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Drug Targets
dc.relation.ispartofjcr3.112
dc.relation.ispartofsjr0,906
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectophthalmic deliverypt
dc.subjectocular bioavailabilitypt
dc.subjectcolloidal drug delivery systemspt
dc.titleColloidal carriers for ophthalmic drug deliveryen
dc.typeResenha
dcterms.licensehttp://eurekaselect.com/209
dcterms.rightsHolderBentham Science Publ Ltd
unesp.author.lattes5361569184579557
unesp.author.orcid0000-0002-4442-2075[1]
unesp.author.orcid0000-0003-3618-8415[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas