Anatomopathological analysis of sentinel and nonsentinel lymph nodes in breast cancer: Hematoxylin-eosin versus immunohistochemistry

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dc.contributor.authorSoares, Cleverson Teixeira
dc.contributor.authorFrederigue-Junior, Ulisses
dc.contributor.authorde Luca, Laurival Antonio
dc.contributor.institutionInst Lauro Souza Lima
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:27:33Z
dc.date.available2014-05-20T15:27:33Z
dc.date.issued2007-10-01
dc.description.abstractThe authors compare the detection of metastases in sentinel lymph nodes (SLNs) and nonsentinel lymph nodes (NSLNs) using hematoxvlin-eosin (HE) staining versus immunohistochemistry (IHC). Thirty-six patients with breast carcinoma undergo exeresis of the primary tumor and of 50 SLNs and 491 NSLNs. Sentinel lymph nodes are sectioned into transverse slices of 2- to 3-mm thickness, and a cytologic smear and a frozen section were obtained from each slice. The slices are completely cut into serial sections at 100-mu m intervals. Two consecutive 4-mu m-thick sections are then obtained from each level and were prepared for HE staining and IHC. Nonsentinel lymph nodes are evaluated similarly to SLNs. The authors obtain 4076 SLN sections and 32 012 NSLN sections, fora total of 36 088 sections. A comparison of HE staining versus IHC based on the total number of sections shows a sensitivity of 93.8%, a negative predictive value of 98.9%, and an accuracy of 99.1 %. The values obtained by HE staining are similar to those obtained by IHC.en
dc.description.affiliationInst Lauro Souza Lima, Lab Anat Patol, BR-17034971 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med, Ctr Avaliacao Mastol, Inst Anat Patol Bauru,Lab Anat Patol, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med, Ctr Avaliacao Mastol, Inst Anat Patol Bauru,Lab Anat Patol, São Paulo, Brazil
dc.format.extent358-368
dc.identifierhttp://dx.doi.org/10.1177/1066896907302124
dc.identifier.citationInternational Journal of Surgical Pathology. Thousand Oaks: Sage Publications Inc., v. 15, n. 4, p. 358-368, 2007.
dc.identifier.doi10.1177/1066896907302124
dc.identifier.issn1066-8969
dc.identifier.urihttp://hdl.handle.net/11449/37505
dc.identifier.wosWOS:000249906100006
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofInternational Journal of Surgical Pathology
dc.relation.ispartofjcr1.188
dc.relation.ispartofsjr0,441
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectsentinel lymph nodept
dc.subjectmetastasispt
dc.subjectimmunohistochemistrypt
dc.titleAnatomopathological analysis of sentinel and nonsentinel lymph nodes in breast cancer: Hematoxylin-eosin versus immunohistochemistryen
dc.typeArtigo
dcterms.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dcterms.rightsHolderSage Publications Inc

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