Prevalence of immune-mediated inner ear disease in non-segmental vitiligo: A cross-sectional study

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dc.contributor.authorMarchioro, Helena Zenedin
dc.contributor.authorde Castro, Caio César Silva
dc.contributor.authorChiesorin, Aline Salete Turatti
dc.contributor.authorBindi, Elaine Weiss
dc.contributor.authorJiacomini, Isabella Gizzi
dc.contributor.authorMiot, Hélio Amante [UNESP]
dc.contributor.institutionSanta Casa Hospital
dc.contributor.institutionPontifícia Universidade Católica do Paraná
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:53:34Z
dc.date.available2023-07-29T13:53:34Z
dc.date.issued2023-07-01
dc.description.abstractBackground: Sensorineural hearing loss (SNHL) is associated with non-segmental vitiligo (NSV); however, the aetiology of SNHL has not been explored. The concomitance of autoimmune disease in vitiligo patients demands the investigation of immune-mediated inner ear disease (IMIED) as a cause of SNHL in NSV. The anti-Hsp70 antibody is a serological marker of IMIED, which may help in the early diagnosis of this disease. Objective: To evaluate the prevalence of IMIED in NSV patients. Methods: Cross-sectional study involving NSV adult patients and a control group, evaluated through audiometry and serological dosage of the anti-Hsp70 antibody. Results: In total, 112 cases and 23 controls were evaluated. Bilateral SNHL was found in 28 (25.0%; 95%CI 17.9%–32.1%) patients and in 1 (4.3%) control (p = 0.019). Six cases (5.4%; 95%CI 2.7%–8.0%) presented bilateral SNHL of unexplained aetiology, and anti-Hsp70 antibody positivity, fulfilling the diagnostic criteria for IMIED. No controls met the diagnostic criteria for IMIED. Serum anti-Hsp70 antibodies were higher in cases with IMIED: median 220.9 vs. 85.1 ng/ml (p = 0.001). Conclusion: The prevalence of IMIED is remarkable in NSV adult patients.en
dc.description.affiliationDepartment of Dermatology Santa Casa Hospital, Praça Rui Barbosa, 694, Centro, PR
dc.description.affiliationDepartment of Dermatology Pontifícia Universidade Católica do Paraná, Rua Imaculada Conceição, 1155, Prado Velho, PR
dc.description.affiliationDepartment of Phonoaudiology Santa Casa Hospital, Praça Rui Barbosa, 694, Centro, PR
dc.description.affiliationDepartment of Basic Patology Universidade Federal do Paraná, Av. Cel. Francisco H. dos Santos, 100, Jardim das Américas, PR
dc.description.affiliationDepartment of Dermatology FMB – UNESP, Distrito de Rubião Júnior, s/n, SP
dc.description.affiliationUnespDepartment of Dermatology FMB – UNESP, Distrito de Rubião Júnior, s/n, SP
dc.identifierhttp://dx.doi.org/10.1016/j.autrev.2023.103336
dc.identifier.citationAutoimmunity Reviews, v. 22, n. 7, 2023.
dc.identifier.doi10.1016/j.autrev.2023.103336
dc.identifier.issn1873-0183
dc.identifier.issn1568-9972
dc.identifier.scopus2-s2.0-85157997018
dc.identifier.urihttp://hdl.handle.net/11449/248781
dc.language.isoeng
dc.relation.ispartofAutoimmunity Reviews
dc.sourceScopus
dc.subjectAutoimmunity
dc.subjectInner ear
dc.subjectSensorineural hearing loss
dc.subjectVitiligo
dc.titlePrevalence of immune-mediated inner ear disease in non-segmental vitiligo: A cross-sectional studyen
dc.typeCarta
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentDermatologia e Radioterapia - FMBpt

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Botucatu - FMB - Faculdade de Medicina