Effects of physical training on serum and pituitary growth hormone contents in diabetic rats
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Curiacos de Almeida Leme, Jose Alexandre [UNESP]
de Araujo, Michel Barbosa [UNESP]
de Moura, Leandro Pereira [UNESP]
Gomes, Ricardo Jose [UNESP]
de Moura, Rodrigo Ferreira [UNESP]
Rogatto, Gustavo Puggina [UNESP]
Rostom de Mello, Maria Alice [UNESP]
Luciano, Eliete [UNESP]
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The present study investigated the effects of moderate physical training on some of the parameters in the GH-IGF axis in experimental diabetic rats. Male Wistar rats were allocated into the following groups: sedentary control, trained control, sedentary diabetic, trained diabetic. Diabetes was induced by alloxan (32 mg/kg, b.w. iv). The physical training protocol consisted of 1 h swimming session/day, 5 days/week for 8 weeks supporting a load corresponding to 90% of maximal lactate steady state. After the experimental period, blood was collected to measure serum glucose, insulin, triglycerides, albumin, insulin-like growth factors-I (IGF-I), and growth hormone (GH). Pituitary gland was removed for GH quantification. Diabetes increased blood glucose and triglycerides and decreased insulin, IGF-I, serum and pituitary GH. Physical training decreased glucose and triglycerides, and also counteracted the reduction of serum IGF-I in diabetic rats. In conclusion, physical training recovered serum IGF-I showing no alteration of serum or pituitary GH levels.
Pituitary, Physical training, Diabetes, Growth hormone and IGF
Pituitary. New York: Springer, v. 12, n. 4, p. 304-308, 2009.