Safety assessment of omeprazole use: A review

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dc.contributor.authorForgerini, Marcela [UNESP]
dc.contributor.authorMieli, Stephania [UNESP]
dc.contributor.authorMastroianni, Patrícia de Carvalho [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T17:05:59Z
dc.date.available2019-10-06T17:05:59Z
dc.date.issued2018-01-01
dc.description.abstractBACKGROUND: Risks regarding hospital admission due to adverse drug reactions and drug interactions from use of omeprazole have been reported. The question guiding the present review was “Which adverse events occur in patients using omeprazole in a Food and Drug Administration-approved and/or off-label manner? It was also proposed to evaluate the safety of use of omeprazole. DESIGN AND SETTING: Qualitative narrative review with critical evaluation, in a public university. METHODS: The PubMed, SCOPUS, LILACS, SciELO, EMBASE and EBSCO databases were searched on July 31, 2018. Studies evaluating adverse events were screened. RESULTS: 72 articles were included, among which 58 reported on adverse drug events (47, adverse drug reactions; 5, drug interactions; and 6, situations of ineffectiveness). 28 adverse drug reactions not described in compendia and drug leaflets were described in these studies: myocardial infarction (6); stroke (2); spontaneous abortion (1); proliferative changes (1); chills (1); heart failure (1); thrombosis (2); and dementia (1), among others. Severe adverse reactions, for instance cardiac problems, Steven-Johnson syndrome and proliferative changes, were identified. The antiplatelet effects of drugs such as clopidogrel, in patients who underwent heart-related surgery, increased the risk of developing cardiac problems, such as cardiovascular death, myocardial infarction and stroke. In newly transplanted patients, decreased absorption of mycophenolate mofetil occurred, thus leading to rejection of transplanted organs. CONCLUSION: Use of omeprazole should be monitored primarily in patients with heart disorders using antiplatelet agents concomitantly, and in newly transplanted patients using mycophenolic acid, in order to avoid serious adverse reactions.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Drugs and Medicines Universidade Estadual Paulista (UNESP)
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUnespDepartment of Drugs and Medicines Universidade Estadual Paulista (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipIdCNPq: 131206/2017-6
dc.description.sponsorshipIdFAPESP: 2013/12681-2
dc.description.sponsorshipIdFAPESP: 2014/03468-6
dc.format.extent557-570
dc.identifierhttp://dx.doi.org/10.1590/1516-3180.2018.0019220318
dc.identifier.citationSao Paulo Medical Journal, v. 136, n. 6, p. 557-570, 2018.
dc.identifier.doi10.1590/1516-3180.2018.0019220318
dc.identifier.fileS1516-31802018000600557.pdf
dc.identifier.issn1516-3180
dc.identifier.scieloS1516-31802018000600557
dc.identifier.scopus2-s2.0-85063259178
dc.identifier.urihttp://hdl.handle.net/11449/190214
dc.language.isoeng
dc.relation.ispartofSao Paulo Medical Journal
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDrug interactions
dc.subjectDrug-related side effects and adverse reactions
dc.subjectProton pump inhibitors
dc.subjectReview
dc.subjectTreatment outcome
dc.titleSafety assessment of omeprazole use: A reviewen
dc.typeResenha
unesp.author.orcid0000-0002-2905-8519[1]
unesp.author.orcid0000-0001-5002-966X[2]
unesp.author.orcid0000-0001-8467-7278[3]
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas