Both alpha(1)- and alpha(2)-adrenoceptors in the Insular Cortex Are Involved in the Cardiovascular Responses to Acute Restraint Stress in Rats

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dc.contributor.authorAlves, Fernando H. F.
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.authorResstel, Leonardo B. M.
dc.contributor.authorCorrea, Fernando M. A.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:11:44Z
dc.date.available2014-12-03T13:11:44Z
dc.date.issued2014-01-03
dc.description.abstractThe insular cortex (IC) is a limbic structure involved in cardiovascular responses observed during aversive threats. However, the specific neurotransmitter mediating IC control of cardiovascular adjustments to stress is yet unknown. Therefore, in the present study we investigated the role of local IC adrenoceptors in the cardiovascular responses elicited by acute restraint stress in rats. Bilateral microinjection of different doses (0.3, 5, 10 and 15 nmol/100 nl) of the selective alpha(1)-adrenoceptor antagonist WB4101 into the IC reduced both the arterial pressure and heart rate increases elicited by restraint stress. However, local IC treatment with different doses (0.3, 5, 10 and 15 nmol/100 nl) of the selective alpha(2)-adrenoceptor antagonist RX821002 reduced restraint-evoked tachycardia without affecting the pressor response. The present findings are the first direct evidence showing the involvement of IC adrenoceptors in cardiovascular adjustments observed during aversive threats. Our findings indicate that IC noradrenergic neurotransmission acting through activation of both alpha(1)- and alpha(2)-adrenoceptors has a facilitatory influence on pressor response to acute restraint stress. Moreover, IC alpha(1)-adrenoceptors also play a facilitatory role on restraint-evoked tachycardiac response.en
dc.description.affiliationUniv Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estudual Paulista UNESP, Dept Nat Act Principles & Toxicol, Sch Pharmaceut Sci Araraquara, Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estudual Paulista UNESP, Dept Nat Act Principles & Toxicol, Sch Pharmaceut Sci Araraquara, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 10/09462-9
dc.format.extent7
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0083900
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 9, n. 1, 7 p., 2014.
dc.identifier.doi10.1371/journal.pone.0083900
dc.identifier.fileWOS000329460800020.pdf
dc.identifier.issn1932-6203
dc.identifier.lattes1117432571971568
dc.identifier.urihttp://hdl.handle.net/11449/113481
dc.identifier.wosWOS:000329460800020
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPLOS ONE
dc.relation.ispartofjcr2.766
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleBoth alpha(1)- and alpha(2)-adrenoceptors in the Insular Cortex Are Involved in the Cardiovascular Responses to Acute Restraint Stress in Ratsen
dc.typeArtigo
dcterms.rightsHolderPublic Library Science
unesp.author.lattes1117432571971568[2]
unesp.author.orcid0000-0002-1942-858X[2]
unesp.author.orcid0000-0003-4067-9524[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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