A comprehensive analysis of malaria transmission in Brazil

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dc.contributor.authorCarlos, Bianca C. [UNESP]
dc.contributor.authorRona, Luisa D. P.
dc.contributor.authorChristophides, George K.
dc.contributor.authorSouza-Neto, Jayme A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionImperial College London
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionNational Institute of Science and Technology in Molecular Entomology
dc.date.accessioned2019-10-06T15:36:48Z
dc.date.available2019-10-06T15:36:48Z
dc.date.issued2019-01-02
dc.description.abstractMalaria remains a serious public health problem in Brazil despite a significant drop in the number of cases in the past decade. We conduct a comprehensive analysis of malaria transmission in Brazil to highlight the epidemiologically most relevant components that could help tackle the disease. We consider factors impacting on the malaria burden and transmission dynamics including the geographical occurrence of both autochthonous and imported infections, the distribution and abundance of malaria vectors and records of natural mosquito infections with Plasmodium. Our analysis identifies three discrete malaria transmission systems related to the Amazon rainforest, Atlantic rainforest and Brazilian coast, respectively. The Amazonian system accounts for 99% of all malaria cases in the country. It is largely due to autochthonous P. vivax and P. falciparum transmission by mosquitoes of the Nyssorhynchus subgenus, primarily Anopheles darlingi. Whilst P. vivax transmission is widespread, P. falciparum transmission is restricted to hotspot areas mostly in the States of Amazonas and Acre. This system is the major source of P. vivax exportation to the extra-Amazonian regions that are also affected by importation of P. falciparum from Africa. The Atlantic system comprises autochthonous P. vivax transmission typically by the bromeliad-associated mosquitoes An. cruzii and An. bellator of the Kerteszia subgenus. An. cruzii also transmits simian malaria parasites to humans. The third, widespread but geographically fragmented, system is found along the Brazilian coast and comprises P. vivax transmission mainly by An. aquasalis. We conclude that these geographically and biologically distinct malaria transmission systems require specific strategies for effective disease control.en
dc.description.affiliationSchool of Agricultural Sciences Department of Bioprocesses and Biotechnology Central Multiuser Laboratory São Paulo State University (UNESP)
dc.description.affiliationInstitute of Biotechnology São Paulo State University (UNESP)
dc.description.affiliationDepartment of Life Sciences Imperial College London
dc.description.affiliationDepartment of Cell Biology Embryology and Genetics Federal University of Santa Catarina (UFSC)
dc.description.affiliationNational Council for Scientific and Technological Development (INCT-EM CNPq) National Institute of Science and Technology in Molecular Entomology
dc.description.affiliationUnespSchool of Agricultural Sciences Department of Bioprocesses and Biotechnology Central Multiuser Laboratory São Paulo State University (UNESP)
dc.description.affiliationUnespInstitute of Biotechnology São Paulo State University (UNESP)
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipRoyal Dublin Society
dc.description.sponsorshipIdWellcome Trust: 107983/Z/15/Z
dc.description.sponsorshipIdCNPq: 401433/2014-5
dc.description.sponsorshipIdRoyal Dublin Society: NF161472
dc.format.extent1-13
dc.identifierhttp://dx.doi.org/10.1080/20477724.2019.1581463
dc.identifier.citationPathogens and Global Health, v. 113, n. 1, p. 1-13, 2019.
dc.identifier.doi10.1080/20477724.2019.1581463
dc.identifier.issn2047-7732
dc.identifier.issn2047-7724
dc.identifier.scopus2-s2.0-85062949047
dc.identifier.urihttp://hdl.handle.net/11449/187461
dc.language.isoeng
dc.relation.ispartofPathogens and Global Health
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAmazon rainforest
dc.subjectAnopheles
dc.subjectAtlantic rainforest
dc.subjectbromeliad malaria
dc.subjectMalaria hotspots
dc.subjectMalaria transmission
dc.subjectPlasmodium falciparum
dc.subjectPlasmodium vivax
dc.titleA comprehensive analysis of malaria transmission in Brazilen
dc.typeResenha

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