Hydrogels Containing Budesonide-Loaded Nanoparticles to Facilitate Percutaneous Absorption for Atopic Dermatitis Treatment Applications

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dc.contributor.authorCampos, Estefânia V. R.
dc.contributor.authorProença, Patricia L. F. [UNESP]
dc.contributor.authorCosta, Tais Germano Da
dc.contributor.authorDe Lima, Renata
dc.contributor.authorHedtrich, Sarah
dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.authorDe Araujo, Daniele Ribeiro
dc.contributor.institutionFederal University of Abc
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Sorocaba (UNISO)
dc.contributor.institutionThe University of British Columbia
dc.date.accessioned2022-05-01T08:45:00Z
dc.date.available2022-05-01T08:45:00Z
dc.date.issued2021-09-10
dc.description.abstractAtopic dermatitis (AD) is a chronic, relapsing inflammatory skin disorder characterized by intense itching and recurrent eczematous lesions. Topical corticosteroids are the first-line treatment to control moderate-to-severe AD; however, prolonged application of corticosteroids is required, which can result in dermal atrophy as a side effect. Drug-delivery systems can provide more effective and targeted therapy strategies. In this study, budesonide (BUD) was encapsulated into chitosan (CS)-coated PLGA nanoparticles, which were further incorporated into poloxamer hydrogels to improve the anti-inflammatory activity and decrease adverse effects. The nanoparticles were prepared by the emulsification-solvent evaporation technique, and their physicochemical characteristics were evaluated. Rheological properties of the hydrogels, such as viscosity and sol-gel transition temperature, were evaluated with and without nanoparticles. In vitro release kinetics and ex vivo drug absorption studies were performed using Franz diffusion cells. The nanoparticles showed a mean diameter of 324 ± 4 nm, positive ζ potential (20 mV) due to CS coating, and high encapsulation efficiency (>90%). The nanoparticles did not show cytotoxic effects in primary human fibroblasts and keratinocytes; however, all formulations induced the generation of reactive oxygen species. Both nanoparticles and hydrogels were able to change the release kinetics of BUD when compared to the nonencapsulated compound. Nanoparticles were not able to surmount the stratum corneum of excised human skin, but the nanoencapsulation facilitated the skin absorption of BUD. The hydrogels containing nanoparticles or not showed non-Newtonian and pseudoplastic behavior. The nanoformulations seem to be a good candidate to deliver glucocorticoids in the skin of AD patients.en
dc.description.affiliationHuman and Natural Sciences Center Federal University of Abc, Sao Paulo
dc.description.affiliationDrugs and Bioactives Delivery Systems Research Group - Sislibio Federal University of Abc, Sao Paulo
dc.description.affiliationDepartment of Environmental Engineering Institute of Science and Technology Sao Paulo State University - Unesp, Sao Paulo
dc.description.affiliationLaboratory for Evaluation of the Bioactivity and Toxicology of Nanomaterials University of Sorocaba (UNISO), Sao Paulo
dc.description.affiliationFaculty of Pharmaceutical Sciences The University of British Columbia
dc.description.affiliationUnespDepartment of Environmental Engineering Institute of Science and Technology Sao Paulo State University - Unesp, Sao Paulo
dc.format.extent4436-4449
dc.identifierhttp://dx.doi.org/10.1021/acsapm.1c00021
dc.identifier.citationACS Applied Polymer Materials, v. 3, n. 9, p. 4436-4449, 2021.
dc.identifier.doi10.1021/acsapm.1c00021
dc.identifier.issn2637-6105
dc.identifier.scopus2-s2.0-85114052938
dc.identifier.urihttp://hdl.handle.net/11449/233466
dc.language.isoeng
dc.relation.ispartofACS Applied Polymer Materials
dc.sourceScopus
dc.subjectatopic dermatitis
dc.subjectbudesonide
dc.subjectpolymeric nanoparticles
dc.subjectthermoresponsive hydrogels
dc.subjecttopical release
dc.titleHydrogels Containing Budesonide-Loaded Nanoparticles to Facilitate Percutaneous Absorption for Atopic Dermatitis Treatment Applicationsen
dc.typeArtigo
unesp.author.orcid0000-0002-9420-7461 0000-0002-9420-7461[1]
unesp.author.orcid0000-0001-8712-1144[4]
unesp.author.orcid0000-0001-6770-3657[5]
unesp.author.orcid0000-0002-2827-2038[6]
unesp.author.orcid0000-0002-9289-4229 0000-0002-9289-4229[7]

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