Interleukin-15 increases Paracoccidioides brasiliensis killing by human neutrophils

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Tavian, Elisandra Garcia [UNESP]
Dias-Meliclo, Luciane Alarcao [UNESP]
Acorci, Michele Janegitz [UNESP]
Bordon-Graciani, Ana Paula [UNESP]
Serrao Peracoli, Maria Terezinha [UNESP]
de Campos Soares, Angela Maria Victoriano [UNESP]

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Academic Press Ltd Elsevier B.V. Ltd


Interleukin-15 is a cytokine produced by a wide range of different cell types, including macrophages, in response to lipopolysaccharide or microbial infection. This cytokine may play a crucial role in the activation of phagocytic cells against pathogens, especially during innate immune response. The effects of IL-15 on human polymorphonuclear leukocyte fungicidal activity against a highly virulent Paracoccidioides brasiliensis strain were investigated. Pretreatment of human neutrophils from healthy individuals with IL-15 for IS h increased cell fungicidal activity in a dose-dependent manner. In addition, the exposure to IL-15 induced an increase in neutrophil oxidative burst as evaluated by superoxide anion and H(2)O(2) release. Catalase inhibited fungicidal activity supporting a role for H(2)O(2) in fungus killing. In contrast, IL-8 and TNF-alpha levels were not affected by IL-15 suggesting that its effects were not mediated by these cytokines. Together, these results show that IL-15 is a potent stimulant of antifungal activities in human neutrophils, at least in part by a mechanism dependent on oxidative metabolism. (c) 2007 Elsevier Ltd. All rights reserved.



IL-15, Paracoccidioides brasiliensis, human neutrophil, hydrogen peroxide, fungicidal activity

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Cytokine. London: Academic Press Ltd- Elsevier B.V. Ltd, v. 41, n. 1, p. 48-53, 2008.