Comparison of inflammatory cytokine profiles in plasma of patients undergoing otorhinological surgery with propofol or isoflurane anesthesia

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dc.contributor.authorMazoti, Marina Azer [UNESP]
dc.contributor.authorBraz, Mariana Gobbo [UNESP]
dc.contributor.authorGolim, Márjorie de Assis [UNESP]
dc.contributor.authorBraz, Leandro Gobbo [UNESP]
dc.contributor.authorDias, Norimar Hernandes [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorBraz, José Reinaldo Cerqueira [UNESP]
dc.contributor.authorFecchio, Denise [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:46Z
dc.date.available2014-05-27T11:30:46Z
dc.date.issued2013-10-01
dc.description.abstractObjective and design: The effects of anesthetics on cytokine release in patients without comorbidities who undergo minor surgery are not well defined. We compared inflammatory cytokine profiles in adult patients undergoing minimally invasive surgery who received isoflurane or propofol anesthesia. Methods: Thirty-four patients without comorbidities undergoing minor surgery were randomly assigned to receive an inhaled anesthetic (isoflurane; n = 16) or an intravenous anesthetic (propofol; n = 18). Blood samples were drawn before premedication and anesthesia (T1), 120 min after anesthesia induction (T2), and on the first post-operative day (T3). Plasma concentrations of interleukins (IL-) 1β, 6, 8, 10 and 12 and tumor necrosis factor (TNF)-α were measured using flow cytometry. Results: The pro-inflammatory cytokine IL-6 was increased in the isoflurane group at T2 and T3 compared to T1 (P < 0.01). In the propofol group, IL-6 and IL-8 were significantly increased at T3 compared to T1. However, there were no significant differences in cytokine concentrations between the isoflurane and propofol groups. Conclusion: An inflammatory response occurred earlier in patients who received an inhaled agent compared with an intravenous anesthetic, but no differences in plasma cytokine profiles were evident between isoflurane and propofol anesthesia in patients without comorbidities undergoing minimally invasive surgeries. © 2013 Springer Basel.en
dc.description.affiliationDepartamento de Patologia Faculdade de Medicina de Botucatu UNESP-Univ Estadual Paulista, Distrito de Rubião Junior, s/n., Botucatu, SP CEP 18618-970
dc.description.affiliationDepartment of Anesthesiology Faculdade de Medicina de Botucatu UNESP-Univ Estadual Paulista, Botucatu SP
dc.description.affiliationBlood Center Faculdade de Medicina de Botucatu UNESP-Univ Estadual Paulista, Botucatu SP
dc.description.affiliationDepartment of Otorhinolaryngology Faculdade de Medicina de Botucatu UNESP-Univ Estadual Paulista, Botucatu SP
dc.description.affiliationUnespDepartamento de Patologia Faculdade de Medicina de Botucatu UNESP-Univ Estadual Paulista, Distrito de Rubião Junior, s/n., Botucatu, SP CEP 18618-970
dc.description.affiliationUnespDepartment of Anesthesiology Faculdade de Medicina de Botucatu UNESP-Univ Estadual Paulista, Botucatu SP
dc.description.affiliationUnespBlood Center Faculdade de Medicina de Botucatu UNESP-Univ Estadual Paulista, Botucatu SP
dc.description.affiliationUnespDepartment of Otorhinolaryngology Faculdade de Medicina de Botucatu UNESP-Univ Estadual Paulista, Botucatu SP
dc.format.extent879-885
dc.identifierhttp://dx.doi.org/10.1007/s00011-013-0643-y
dc.identifier.citationInflammation Research, v. 62, n. 10, p. 879-885, 2013.
dc.identifier.doi10.1007/s00011-013-0643-y
dc.identifier.issn1023-3830
dc.identifier.issn1420-908X
dc.identifier.lattes5051118752980903
dc.identifier.lattes7199562550978496
dc.identifier.lattes5530023010203804
dc.identifier.orcid0000-0003-4413-226X
dc.identifier.scopus2-s2.0-84884676075
dc.identifier.urihttp://hdl.handle.net/11449/76682
dc.identifier.wosWOS:000324270100002
dc.language.isoeng
dc.relation.ispartofInflammation Research
dc.relation.ispartofjcr2.990
dc.relation.ispartofsjr1,062
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCytokines
dc.subjectFlow cytometry
dc.subjectInflammatory response
dc.subjectIsoflurane
dc.subjectMinor surgical procedures
dc.subjectPropofol
dc.titleComparison of inflammatory cytokine profiles in plasma of patients undergoing otorhinological surgery with propofol or isoflurane anesthesiaen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
unesp.author.lattes7199562550978496
unesp.author.lattes5051118752980903
unesp.author.lattes5530023010203804
unesp.author.orcid0000-0002-1927-8729[4]
unesp.author.orcid0000-0003-4413-226X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Patologia - FMB
Artigos - Anestesiologia - FMB
Artigos - Oftalmo/Otorrino e CCP - FMB