Low expression of human histocompatibility soluble leukocyte antigen-G (HLA-G5) in invasive cervical cancer with and without metastasis, associated with Papilloma Virus (HPV)

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dc.contributor.authorGuimarães, M. C. M.
dc.contributor.authorSoares, Christiane Pienna [UNESP]
dc.contributor.authorDonadi, Eduardo Antônio
dc.contributor.authorDerchain, Sophie F. M.
dc.contributor.authorAndrade, Liliana Aparecida Lucci de Angelo
dc.contributor.authorSilva, Tarsia G. A. [UNESP]
dc.contributor.authorHassumi, M. K.
dc.contributor.authorSimões, Renata T.
dc.contributor.authorMiranda, Fabiana A.
dc.contributor.authorLira, Régia C. P.
dc.contributor.authorCrispim, Janaína Oliveira
dc.contributor.authorSoares, Edson Garcia
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:56:16Z
dc.date.available2016-01-28T16:56:16Z
dc.date.issued2010
dc.description.abstractHuman leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex class Ib molecule that acts as a specific immunosuppressor. Some studies have demonstrated that human papillomavirus (HPV) seems to be involved in lower or absent HLA-G expression, particularly in cervical cancer. In this study, we performed a cross-sectional study, systematically comparing the qualitative expression of the HLA-G5 isoform in invasive cervical carcinoma (ICC), stratifying patients according to the presence [ICC with metastasis (ICCW)] and absence [ICC without metastasis (ICCWT)] of metastasis, correlating these findings with interference of HPV and demographic and clinical variables. Seventy-nine patients with a diagnosis of ICC were stratified into two groups: ICCWT (n=52 patients) and ICCW (n=27). Two biopsies were collected from each patient (one from the tumor lesion and one from a lymph node). Immunohistochemistry analyses were performed for the HLA-G5 isoform, for HPV detection, and virus typing. HLA-G5 isoform molecules were detected in 25 cases (31.6%), 17 (32.7%) without metastasis and 8 (29.6%) with metastasis. HPV was detected in the cervical lesions of 74 patients (93.7%), but low expression of the HLA-G5 isoform was observed in all HPV-related cases. These findings are important; however, additional studies are necessary to identify the influence of HPV with HLA-G5 isoform expression on invasive cervical malignancies.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rua Expedicionários do Brasil, 1621, Centro, CEP 14801902, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rua Expedicionários do Brasil, 1621, Centro, CEP 14801902, SP, Brasil
dc.format.extent405-411
dc.identifierhttp://dx.doi.org/10.1369/jhc.2009.954131
dc.identifier.citationThe Journal of Histochemistry and Cytochemistry, v. 58, n. 5, p. 405-411, 2010.
dc.identifier.doi10.1369/jhc.2009.954131
dc.identifier.issn0022-1554
dc.identifier.lattes3112803094228207
dc.identifier.lattes1577479770560931
dc.identifier.lattes3285282420989060
dc.identifier.lattes2315073053423747
dc.identifier.lattes1768025290373669
dc.identifier.lattes9338770260143276
dc.identifier.lattes2382521330746598
dc.identifier.lattes8778713382135771
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.urihttp://hdl.handle.net/11449/133710
dc.language.isoeng
dc.relation.ispartofThe Journal of Histochemistry and Cytochemistry
dc.relation.ispartofjcr2.816
dc.relation.ispartofsjr1,344
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectInvasive cervical carcinomaen
dc.subjectHLA-G5 isoformen
dc.subjectHPVen
dc.subjectImmunohistochemistryen
dc.subjectPCRen
dc.titleLow expression of human histocompatibility soluble leukocyte antigen-G (HLA-G5) in invasive cervical cancer with and without metastasis, associated with Papilloma Virus (HPV)en
dc.typeArtigo
unesp.author.lattes3112803094228207
unesp.author.lattes1577479770560931
unesp.author.lattes3285282420989060
unesp.author.lattes2315073053423747
unesp.author.lattes9338770260143276
unesp.author.lattes2382521330746598
unesp.author.lattes8778713382135771
unesp.author.lattes1768025290373669[2]
unesp.author.orcid0000-0003-1740-7360[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas