Determination of Analgesics (Dipyrone and Acetaminophen) in Pharmaceutical Preparations by Cyclic Voltammetry at a Copper(II) Hexacyanoferrate(III) Modified Carbon Paste Electrode

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dc.contributor.authorTeixeira, Marcos F. S. [UNESP]
dc.contributor.authorMarcolino-Junior, Luiz H.
dc.contributor.authorFatibello-Filho, Orlando
dc.contributor.authorMoraes, Fernando C.
dc.contributor.authorNunes, Ronaldo S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:23:03Z
dc.date.available2014-05-20T13:23:03Z
dc.date.issued2009-10-01
dc.description.abstractCopper(II) hexacyanoferrate(III) (CuHCF) modified carbon paste electrode was used for the electroanalytical determination of dipyrone and acetaminophen in pharmaceutical preparations by cyclic voltammetry. Several parameters were investigated for the optimization of the sensor such as composition of the electrode, electrolytic solution, effect of pH, scan rate of potential and interference. The best conditions were found for an electrode composition in mass of 20% CuHCF, 55% graphite and 25% mineral oil in acetate buffer containing 0.05 mol L(-1) of NaCl. The analytical curve was linear in the dipyrone and acetaminophen concentration ranged from 1.25 x 10(-5) mol L(-1) to 1.23 x 10(-3) and 2.84 x 10(-4) to 2.59 x 10(-3) mol L(-1) respectively, being successfully applied to the determination of dipyrone and acetaminophen in pharmaceutical preparations. The CuHCF modified carbon paste electrode presented comparable results to those obtained using iodimetry and ultraviolet spectrophotometry methods, respectively.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias & Tecnol, Dept Fis Quim & Biol, UNESP, BR-19060900 Presidente Prudente, SP, Brazil
dc.description.affiliationUniversidade Federal do Paraná (UFPR), Dept Quim, Curitiba, SP, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Quim, BR-13560 São Carlos, SP, Brazil
dc.description.affiliationUSP, Dept Quim & Fis Mol, IQSC, São Carlos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias & Tecnol, Dept Fis Quim & Biol, UNESP, BR-19060900 Presidente Prudente, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 474367/2004-5
dc.description.sponsorshipIdFAPESP: 05/01296-4
dc.description.sponsorshipIdFAPESP: 06/07191-2
dc.format.extent303-310
dc.identifierhttp://dx.doi.org/10.2174/157341109789077759
dc.identifier.citationCurrent Analytical Chemistry. Sharjah: Bentham Science Publ Ltd, v. 5, n. 4, p. 303-310, 2009.
dc.identifier.doi10.2174/157341109789077759
dc.identifier.issn1573-4110
dc.identifier.urihttp://hdl.handle.net/11449/6879
dc.identifier.wosWOS:000271373600002
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Analytical Chemistry
dc.relation.ispartofjcr1.000
dc.relation.ispartofsjr0,274
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectModified carbon paste electrodeen
dc.subjectCopper(II) hexacyanoferrate(III)en
dc.subjectVoltammetric determinationen
dc.subjectAnalgesicsen
dc.subjectPharmaceutical preparationsen
dc.titleDetermination of Analgesics (Dipyrone and Acetaminophen) in Pharmaceutical Preparations by Cyclic Voltammetry at a Copper(II) Hexacyanoferrate(III) Modified Carbon Paste Electrodeen
dc.typeArtigo
dcterms.licensehttp://www.benthamscience.com/permission.php
dcterms.rightsHolderBentham Science Publ Ltd
unesp.author.orcid0000-0002-5001-5038[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Tecnologia, Presidente Prudentept

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