Development and application of a portable instrument for drugs analysis in pharmaceutical preparations

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dc.contributor.authorRibeiro, Paulo Roberto da Silva
dc.contributor.authorPezza, Helena Redigolo [UNESP]
dc.contributor.authorPezz, Leonardo [UNESP]
dc.contributor.authorLima, Liliane Spazzapam [UNESP]
dc.contributor.authorTubino, Matthieu
dc.contributor.institutionFederal University of Maranhão
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2018-12-11T17:26:22Z
dc.date.available2018-12-11T17:26:22Z
dc.date.issued2015-07-01
dc.description.abstractThis article describes the application and performance of an inexpensive, simple and portable device for colorimetric quantitative determination of drugs in pharmaceutical preparations. The sensor is a light detector resistor (LDR) incorporated into a black PTFE cell and coupled to a low-cost multimeter (Ohmmeter). Quantitative studies were performed with captopril/p-chloranil/H2O2 and methyldopa/ ammonium molybdate systems. Calibration curves were obtained by plotting the electrical resistance of the LDR against the concentration of the colored species in the ranges 1.84 x 10-4 to 1.29 x 10-3 mol L-1 and 5.04 x 10-4 to 2.52 x 10-3 mol L-1 for captopril/p-chloranil/H2O2 and methyldopa/ammonium molybdate systems, respectively, exhibiting good coefficients of determination. Statistical analysis of the results obtained showed no significant difference between the proposed methodologies and the official reported methods, as evidenced by the t-test and variance ratio at a 95% confidence level. The results of this study demonstrate the applicability of the instrument for simple, accurate, precise, fast, in situ and low-cost colorimetric analysis of drugs in pharmaceutical products.en
dc.description.affiliationCentre for Social Science Health and Technology Federal University of Maranhão
dc.description.affiliationInstitute of Chemistry São Paulo State University UNESP
dc.description.affiliationDepartment of Analytical Chemistry Institute of Chemistry State University of Campinas UNICAMP
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University UNESP
dc.format.extent699-708
dc.identifierhttp://dx.doi.org/10.1590/S1984-82502015000300022
dc.identifier.citationBrazilian Journal of Pharmaceutical Sciences, v. 51, n. 3, p. 699-708, 2015.
dc.identifier.doi10.1590/S1984-82502015000300022
dc.identifier.fileS1984-82502015000300699.pdf
dc.identifier.issn2175-9790
dc.identifier.issn1984-8250
dc.identifier.scieloS1984-82502015000300699
dc.identifier.scopus2-s2.0-84948764121
dc.identifier.urihttp://hdl.handle.net/11449/177622
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.relation.ispartofsjr0,214
dc.relation.ispartofsjr0,214
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDrugs/ quantitative analysis
dc.subjectDrugs/dosage
dc.subjectInstrumentation/drugs dosage
dc.subjectOptical sensor/application/colorimetric analysis
dc.subjectPharmaceutical formulations/quality control
dc.titleDevelopment and application of a portable instrument for drugs analysis in pharmaceutical preparationsen
dc.typeArtigo

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