Tissue Response and Immunoexpression of Interleukin 6 Promoted by Tricalcium Silicate–based Repair Materials after Subcutaneous Implantation in Rats
dc.contributor.author | Andrade, Aline S. [UNESP] | |
dc.contributor.author | Silva, Guilherme F. [UNESP] | |
dc.contributor.author | Camilleri, Josette | |
dc.contributor.author | Cerri, Estela S. [UNESP] | |
dc.contributor.author | Guerreiro-Tanomaru, Juliane M. [UNESP] | |
dc.contributor.author | Cerri, Paulo S. [UNESP] | |
dc.contributor.author | Tanomaru-Filho, Mário [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | University of Birmingham | |
dc.date.accessioned | 2018-12-11T17:17:49Z | |
dc.date.available | 2018-12-11T17:17:49Z | |
dc.date.issued | 2018-03-01 | |
dc.description.abstract | Introduction: The aim of the present study was to evaluate the inflammatory response induced by experimental tricalcium silicate cement with 20% zirconium oxide (TSC) and MTA Plus (MTAP; Avalon Biomed Inc, Bradenton, FL) in rat subcutaneous tissues. Methods: Polyethylene tubes were filled with TSC (n = 20) and MTAP (n = 20) and implanted in the dorsal subcutaneous tissues of 32 rats. Empty tubes were used as the control (control group [CG], n = 20). After 7, 15, 30, and 60 days, the tubes with connective tissue were removed, and the inflammatory cells and immunolabeled cells for interleukin 6 (IL-6) were counted. Data were statistically analyzed using analysis of variance and the Tukey test (P ≤.05). Results: An increased number of inflammatory and immunolabeled cells for IL-6 were observed at 7 days. The number of inflammatory cells was higher for TSC and MTAP than the CG (P <.001) at 7 days; after 30 and 60 days, no significant differences were observed among the TSC, MTAP, and CG (P =.955). The number of immunolabeled cells for IL-6 was similar for TSC, MTAP, and CG at all evaluated periods. A gradual and significant decrease was observed in the number of inflammatory cells and IL-6–immunopositive cells. At 60 days, the capsules adjacent to TSC and MTAP exhibited fibroblasts and bundles of collagen fibers. Conclusions: TSC and MTAP caused a similar subcutaneous reaction in rats, suggesting that they are biocompatible and present similar immune responses. | en |
dc.description.affiliation | Department of Restorative Dentistry Araraquara Dental School UNESP–São Paulo State University | |
dc.description.affiliation | Department of Morphology Araraquara Dental School UNESP–São Paulo State University Araraquara | |
dc.description.affiliation | Institute of Clinical Sciences College of Medical and Dental Sciences University of Birmingham | |
dc.description.affiliationUnesp | Department of Restorative Dentistry Araraquara Dental School UNESP–São Paulo State University | |
dc.description.affiliationUnesp | Department of Morphology Araraquara Dental School UNESP–São Paulo State University Araraquara | |
dc.format.extent | 458-463 | |
dc.identifier | http://dx.doi.org/10.1016/j.joen.2017.12.006 | |
dc.identifier.citation | Journal of Endodontics, v. 44, n. 3, p. 458-463, 2018. | |
dc.identifier.doi | 10.1016/j.joen.2017.12.006 | |
dc.identifier.file | 2-s2.0-85041613454.pdf | |
dc.identifier.issn | 0099-2399 | |
dc.identifier.scopus | 2-s2.0-85041613454 | |
dc.identifier.uri | http://hdl.handle.net/11449/175843 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Endodontics | |
dc.relation.ispartofsjr | 1,585 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Scopus | |
dc.subject | Biocompatibility | |
dc.subject | immunohistochemistry | |
dc.subject | interleukin 6 | |
dc.subject | tricalcium Silicate | |
dc.subject | zirconium oxide | |
dc.title | Tissue Response and Immunoexpression of Interleukin 6 Promoted by Tricalcium Silicate–based Repair Materials after Subcutaneous Implantation in Rats | en |
dc.type | Artigo | |
unesp.author.orcid | 0000-0002-2574-4706[7] |
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