Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment

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dc.contributor.authorDos Santos Picanço, Leide Caroline
dc.contributor.authorOzela, Priscilla F.
dc.contributor.authorBrito, Maiara de Fátima de Brito
dc.contributor.authorPinheiro, Abraão A.
dc.contributor.authorPadilha, Elias C. [UNESP]
dc.contributor.authorBraga, Francinaldo S.
dc.contributor.authorda Silva, Carlos Henrique Tomich de Paula
dc.contributor.authorDos Santos, Cleydson Breno Rodrigues
dc.contributor.authorRosa, Joaquín M. C.
dc.contributor.authorHage-Melim, Lorane Izabel da Silva
dc.contributor.institutionUniversidade Federal do Amapá
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversity Granada
dc.date.accessioned2018-12-11T17:22:40Z
dc.date.available2018-12-11T17:22:40Z
dc.date.issued2018-01-01
dc.description.abstractDementia is characterized by the impairment of cognition and behavior of people over 65 years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the world, as approximately 47 million people are affected by this disease and the tendency is that this number will increase to 62% by 2030. Two microscopic features assist in the characterization of the disease, the amyloid plaques and neurofibrillary agglomerates. All these factors are responsible for the slow and gradual deterioration of memory that affect language, personality or cognitive control. For the AD diagnosis, neuropsychological tests are performed in different spheres of cognitive functions but since not all cognitive functions may be affected, cerebrospinal fluid biomarkers are used along with these tests. To date, cholinesterase inhibitors are used as treatment, they are the only drugs that have shown significant improvements in the cognitive functions of AD patients. Despite the proven effectiveness of cholinesterase inhibitors, an AD carrier, even while being treated, is continually subjected to progressive degeneration of the neuronal tissue. For this reason, other biochemical pathways associated with the pathophysiology of AD have been explored as alternatives to the treatment of this condition such as inhibition of β-secretase and glycogen synthase kinase-3β. The present study aims to conduct a review of the epidemiology, pathophysiology, symptoms, diagnosis and treatment of Alzheimer's disease, emphasizing the research and development of new therapeutic approaches.en
dc.description.affiliationLaboratório de Química Farmacêutica e Medicinal (PharMedChem) Universidade Federal do Amapá
dc.description.affiliationFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP) Campus Araraquara Departamento de Princípios Ativos Naturais e Toxicologia Araraquara
dc.description.affiliationLaboratório de Modelagem e Química Computacional Universidade Federal do Amapá
dc.description.affiliationLaboratório Computacional de Química Farmacêutica Departamento de Ciencias Farmaceuticas Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo
dc.description.affiliationChemical Department of Pharmaceutical and Organic Faculty of Pharmacy University Campus of cartuja University Granada
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP) Campus Araraquara Departamento de Princípios Ativos Naturais e Toxicologia Araraquara
dc.description.sponsorshipUniversidade de São Paulo
dc.format.extent3141-3159
dc.identifierhttp://dx.doi.org/10.2174/0929867323666161213101126
dc.identifier.citationCurrent Medicinal Chemistry, v. 25, n. 26, p. 3141-3159, 2018.
dc.identifier.doi10.2174/0929867323666161213101126
dc.identifier.issn1875-533X
dc.identifier.issn0929-8673
dc.identifier.scopus2-s2.0-85053112872
dc.identifier.urihttp://hdl.handle.net/11449/176829
dc.language.isoeng
dc.relation.ispartofCurrent Medicinal Chemistry
dc.relation.ispartofsjr1,015
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAcetylcholinesterase
dc.subjectAlzheimer's disease
dc.subjectGlycogen synthase kinase-3β
dc.subjectPathophysiology
dc.subjectTreatment
dc.subjectβ-secretase
dc.titleAlzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatmenten
dc.typeResenha
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas