Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

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dc.contributor.authorFerreira, Gonzalo
dc.contributor.authorBlasina, Fernanda
dc.contributor.authorRodríguez Rey, Marianela
dc.contributor.authorAnesetti, Gabriel
dc.contributor.authorSapiro, Rosana
dc.contributor.authorChavarría, Luisina
dc.contributor.authorCardozo, Romina
dc.contributor.authorRey, Grazzia
dc.contributor.authorSobrevia, Luis [UNESP]
dc.contributor.authorNicolson, Garth L.
dc.contributor.institutionUniversidad de la Republica
dc.contributor.institutionPontificia Universidad Católica de Chile
dc.contributor.institutionUniversidad de Sevilla
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Queensland
dc.contributor.institutionUniversity Medical Center Groningen
dc.contributor.institutionThe Institute for Molecular Medicine
dc.date.accessioned2022-04-28T19:45:52Z
dc.date.available2022-04-28T19:45:52Z
dc.date.issued2022-01-01
dc.description.abstractDuring pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level.en
dc.description.affiliationLaboratory of Ion Channels Biological Membranes and Cell Signaling Dept. of Biophysics Facultad de Medicina Universidad de la Republica
dc.description.affiliationDept. of Neonatology Facultad de Medicina Universidad de la Republica
dc.description.affiliationDept. of Histology and Development Facultad de Medicina Universidad de la Republica
dc.description.affiliationDept. of Clinical Ginecology and Obstetrics B Facultad de Medicina Universidad de la Republica
dc.description.affiliationCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile
dc.description.affiliationDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla
dc.description.affiliationMedical School Faculty of Medicine Sao Paulo State University (UNESP)
dc.description.affiliationUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland
dc.description.affiliationDepartment of Pathology and Medical Biology University of Groningen University Medical Center Groningen
dc.description.affiliationDepartment of Molecular Pathology The Institute for Molecular Medicine
dc.description.affiliationUnespMedical School Faculty of Medicine Sao Paulo State University (UNESP)
dc.description.sponsorshipAgencia Nacional de Investigación e Innovación
dc.description.sponsorshipComisión Sectorial de Investigación Científica
dc.description.sponsorshipRijksuniversiteit Groningen
dc.description.sponsorshipUniversidad de la República Uruguay
dc.description.sponsorshipFondo Nacional de Desarrollo Científico y Tecnológico
dc.description.sponsorshipIdFondo Nacional de Desarrollo Científico y Tecnológico: 1190316
dc.identifierhttp://dx.doi.org/10.1016/j.bbadis.2021.166285
dc.identifier.citationBiochimica et Biophysica Acta - Molecular Basis of Disease, v. 1868, n. 1, 2022.
dc.identifier.doi10.1016/j.bbadis.2021.166285
dc.identifier.issn1879-260X
dc.identifier.issn0925-4439
dc.identifier.scopus2-s2.0-85116931951
dc.identifier.urihttp://hdl.handle.net/11449/222627
dc.language.isoeng
dc.relation.ispartofBiochimica et Biophysica Acta - Molecular Basis of Disease
dc.sourceScopus
dc.subjectBacteria
dc.subjectMaternal-fetal interphase
dc.subjectMycoplasma
dc.subjectNeonates
dc.subjectPregnancy
dc.subjectViruses
dc.titlePathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseasesen
dc.typeArtigo

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