Beneficial effects of dietary copper supplementation on serum lipids and antioxidant defenses in rats

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dc.contributor.authorGalhardi, C. M.
dc.contributor.authorDiniz, Y. S.
dc.contributor.authorRodrigues, H. G.
dc.contributor.authorFaine, L. A.
dc.contributor.authorBurneiko, R. C.
dc.contributor.authorRibas, B. O.
dc.contributor.authorNovelli, ELB
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Salud Carlos III
dc.date.accessioned2014-05-20T13:53:16Z
dc.date.available2014-05-20T13:53:16Z
dc.date.issued2005-01-01
dc.description.abstractBackground: A nutrition experiment was utilized to investigate the effects of two levels of dietary copper (Cu) supplementation on lipid profile and antioxidant defenses in serum of rats. Methods: Male Wistar rats (180-200 g; n = 10) were divided into three groups: control group (A), fed a basal diet with 6 mu g Cu/g, and rats fed a basal diet with Cu (CuSO4) supplementation from aqueous solutions, for 4 weeks at the final concentrations of 2 mg Cu/rat (B) and 3 mg Cu/rat (C). Results: No significant changes were observed in final body weight, body weight gain, food consumption, total serum protein and high-density lipoprotein. Cu supplementation reduced the triacylglycerol (TG), total cholesterol and low-density lipoprotein (LDL-C). The LDL-C/TG ratio and total antioxidant substances (TAS) were higher in (B) and (C) groups than in (A) group. There was a positive correlation between Cu supplementation and ceruloplasmin levels. The markers of oxidative stress, lipid hydroperoxide and lipoperoxide were decreased with Cu supplementation. No alterations were observed in superoxide dismutase, indicating saturation of Cu enzyme site. The glutathione peroxidase activities (GSH-Px) were increased in both Cu-supplemented groups. Considering that a copper-selenium interaction can affect mineral availability of both elements, the effects of Cu on TAS and GSH-Px activities were associated with increased selenium disposal. Conclusions: Dietary Cu supplementation had beneficial effects on lipid profile by improving endogenous antioxidant defenses and decreasing the oxidative stress in vivo. Copyright (C) 2005 S. Karger AG, Basel.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Quim & Bioquim, Inst Biol Sci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Postgrad Course Clin Cardiol, Fac Med, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationInst Salud Carlos III, Natl Ctr Environm Hlth, Dept Toxicol, Madrid, Spain
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Quim & Bioquim, Inst Biol Sci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Postgrad Course Clin Cardiol, Fac Med, BR-18618000 Botucatu, SP, Brazil
dc.format.extent283-288
dc.identifierhttp://dx.doi.org/10.1159/000087294
dc.identifier.citationAnnals of Nutrition and Metabolism. Basel: Karger, v. 49, n. 5, p. 283-288, 2005.
dc.identifier.doi10.1159/000087294
dc.identifier.issn0250-6807
dc.identifier.urihttp://hdl.handle.net/11449/18998
dc.identifier.wosWOS:000232002700001
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofAnnals of Nutrition and Metabolism
dc.relation.ispartofjcr3.051
dc.relation.ispartofsjr1,317
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcopperpt
dc.subjectlipid profilept
dc.subjectoxidative stresspt
dc.subjecttotal antioxidant substancespt
dc.titleBeneficial effects of dietary copper supplementation on serum lipids and antioxidant defenses in ratsen
dc.typeArtigo
dcterms.licensehttp://www.karger.com/Services/RightsPermissions
dcterms.rightsHolderKarger
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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