Case for diagnosis. Cutaneous small vessel vasculitis (anti-proteinase 3 positive), fever, hemoptysis, and lung cavitation in an adult

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Campos, Luana Moraes [UNESP]
Re, Mariana Righetto de [UNESP]
Lacerda, Priscila Neri [UNESP]
Miot, Helio Amante [UNESP]

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Elsevier B.V.


Small vessel vasculitis with anti-proteinase antibodies 3 is an atypical clinical presentation of tuberculosis. The authors present the case of a 47-year-old male patient, with palpable purpura and palmoplantar hemorrhagic blisters, with subsequent dissemination. He presented severe pulmonary symptoms with cavitation, fever, hemoptysis, and high levels of anti-proteinase 3. Histopathological assessment of the skin revealed small vessel vasculitis; pulmonary histopathology showed granulomas with caseation. Bronchoalveolar lavage was positive for alcohol-acid-fast bacilli. In countries with a high prevalence of tuberculosis, the presence of autoantibodies in a patient with vasculitis, fever, and pulmonary cavitation requires investigation of infectious causes. (C) 2021 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U.



Anti-neutrophil cytoplasmic antibodies, Anti-neutrophil cytoplasmic antibody-associated vasculitis, Tuberculosis, Vasculitis

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Anais Brasileiros De Dermatologia. New York: Elsevier Science Inc, v. 96, n. 2, p. 240-242, 2021.