LC Evaluation of In Vitro Release of AZT from Microemulsions

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dc.contributor.authorCarvalho, Flavia Chiva [UNESP]
dc.contributor.authorBarbi, Mariana da Silva [UNESP]
dc.contributor.authorGremião, Maria Palmira Daflon [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:54Z
dc.date.available2014-05-20T13:24:54Z
dc.date.issued2009-06-01
dc.description.abstractA reversed phase LC method was developed and validated to analyze the in vitro release of AZT from microemulsions. A mobile phase of acetonitrile:water (15:85) was used. The method validation showed good selectivity and linearity (r = 0.9993) for sample concentrations ranging from 0.6 to 100.0 mu g mL(-1). The RSD values (0.7-4.3%) and percentage recovery (88.1-109.8%) were within acceptable limits. The limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.012 and 0.041 mu g mL(-1). Quantitative analysis of the values obtained in the drug release assay indicates that the microemulsions used promote sustained release of AZT, which follows a Fickian diffusion mechanism.en
dc.description.affiliationSão Paulo State Univ, UNESP, Coll Pharmaceut Sci, Araraquara, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Coll Pharmaceut Sci, Araraquara, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent207-211
dc.identifierhttp://dx.doi.org/10.1365/s10337-009-1015-1
dc.identifier.citationChromatographia. Wiesbaden: Vieweg, v. 69, p. 207-211, 2009.
dc.identifier.doi10.1365/s10337-009-1015-1
dc.identifier.issn0009-5893
dc.identifier.lattes9129780536724256
dc.identifier.urihttp://hdl.handle.net/11449/7849
dc.identifier.wosWOS:000267330400016
dc.language.isoeng
dc.publisherVieweg
dc.relation.ispartofChromatographia
dc.relation.ispartofjcr1.401
dc.relation.ispartofsjr0,514
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectColumn liquid chromatographyen
dc.subjectIn vitro drug releaseen
dc.subjectDrug delivery systemen
dc.subjectZidovudineen
dc.titleLC Evaluation of In Vitro Release of AZT from Microemulsionsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderVieweg
unesp.author.lattes9129780536724256
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas