Anti-Trichophyton Activity of Protocatechuates and Their Synergism with Fluconazole

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dc.contributor.authorSoares, Luciana Arantes [UNESP]
dc.contributor.authorGullo, Fernanda Patricia [UNESP]
dc.contributor.authorOrlandi Sardi, Janaina de Cassia [UNESP]
dc.contributor.authorPitangui, Nayla de Souza [UNESP]
dc.contributor.authorCosta-Orlandi, Caroline Barcelos [UNESP]
dc.contributor.authorSangalli-Leite, Fernanda [UNESP]
dc.contributor.authorScorzoni, Liliana [UNESP]
dc.contributor.authorRegasini, Luis Octavio [UNESP]
dc.contributor.authorPetronio, Maicon Segalla [UNESP]
dc.contributor.authorSouza, Patricia Fernanda [UNESP]
dc.contributor.authorSiqueira Silva, Dulce Helena [UNESP]
dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.authorFusco-Almeida, Ana Marisa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:11:42Z
dc.date.available2014-12-03T13:11:42Z
dc.date.issued2014-01-01
dc.description.abstractDermatophytosis and superficial mycosis are a major global public health problem that affects 20-25% of the world's population. The increase in fungal resistance to the commercially available antifungal agents, in conjunction with the limited spectrum of action of such drugs, emphasises the need to develop new antifungal agents. Natural products are attractive prototypes for antifungal agents due to their broad spectrum of biological activities. This study aimed to verify the antifungal activity of protocatechuic acid, 3,4-diacetoxybenzoic, and fourteen alkyl protocatechuates (3,4-dihydroxybenzoates) against Trichophyton rubrum and Trichophyton mentagrophytes and to further assess their activities when combined with fluconazole. Susceptibility and synergism assays were conducted as described in M38-A2 (CLSI), with modifications. Three strains of Trichophyton rubrum and three strains of Trichophyton mentagrophytes were used in this work. The pentyl, hexyl, heptyl, octyl, nonyl, and decyl protocatechuates showed great fungicidal effects, with minimum inhibitory concentration (MIC) values ranging from 0.97 to 7.8 mg/L. Heptyl showed a synergistic activity (FIC index = 0.49), reducing the MIC of fluconazole by fourfold. All substances tested were safe, especially the hexyl, heptyl, octyl, and nonyl compounds, all of which showed a high selectivity index, particularly in combination with fluconazole. These ester associations with fluconazole may represent a promising source of prototypes in the search for anti-Trichophyton therapeutic agents.en
dc.description.affiliationUNESP, Fac Pharmaceut Sci, Dept Clin Anal, Lab Clin Mycol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Clin Mycol, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Pharmaceut Sci, Dept Clin Anal, Lab Clin Mycol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Clin Mycol, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipPADC (Support Program for Scientific, Faculty of Pharmaceutical Sciences, UNESP)
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1155/2014/957860
dc.identifier.citationEvidence-based Complementary And Alternative Medicine. New York: Hindawi Publishing Corporation, 9 p., 2014.
dc.identifier.doi10.1155/2014/957860
dc.identifier.fileWOS000338078800001.pdf
dc.identifier.issn1741-427X
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.urihttp://hdl.handle.net/11449/113431
dc.identifier.wosWOS:000338078800001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine
dc.relation.ispartofjcr2.064
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleAnti-Trichophyton Activity of Protocatechuates and Their Synergism with Fluconazoleen
dc.typeArtigo
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes3716273524139678[13]
unesp.author.orcid0000-0002-1516-7765[11]
unesp.author.orcid0000-0002-5752-6367[5]
unesp.author.orcid0000-0002-8059-0826[12]
unesp.author.orcid0000-0002-2115-8988[13]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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