Physicochemical properties, cytotoxicity and bioactivity of a ready-to-use bioceramic repair material

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dc.contributor.authorCampi, Lívia Bueno [UNESP]
dc.contributor.authorRodrigues, Elisandra Márcia [UNESP]
dc.contributor.authorTorres, Fernanda Ferrari Esteves [UNESP]
dc.contributor.authorReis, José Maurício Dos Santos Nunes [UNESP]
dc.contributor.authorGuerreiro-Tanomaru, Juliane Maria [UNESP]
dc.contributor.authorTanomaru-Filho, Mário [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-07-29T13:45:12Z
dc.date.available2023-07-29T13:45:12Z
dc.date.issued2023-01-01
dc.description.abstractThe aim of this study was to evaluate the physicochemical properties, cytotoxicity and bioactivity of a ready-to-use bioceramic material, Bio-C Repair (Angelus), in comparison with White MTA (Angelus) and Biodentine (Septodont). The physicochemical properties of setting time, radiopacity, pH, solubility, dimensional and volumetric changes were evaluated. Biocompatibility and bioactivity were assessed in Saos-2 osteoblast cell cultures by the MTT assay 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), Neutral Red (NR), Alizarin Red (ARS), and cell migration tests. Statistical analysis was performed by ANOVA, Tukey or Bonferroni tests (α = 0.05). Bio-C Repair had the longest setting time (p < 0.05), but radiopacity and solubility were accordance with the ISO 6876/2012 standards, besides linear expansion. Bio-C Repair and MTA had similar volumetric change (p > 0.05); lower than Biodentine (p < 0.05). All the materials evaluated had an alkaline pH. Bio-C Repair was cytocompatible and promoted mineralized nodule deposition in 21 days and cell migration in 3 days. In conclusion, Bio-C Repair had adequate radiopacity above 3mm Al, solubility less than 3%, dimensional expansion, and low volumetric change. In addition, Bio-C Repair promoted an alkaline pH and presented bioactivity and biocompatibility similar to MTA and Biodentine, showing potential for use as a repair material.en
dc.description.affiliationDepartment of Restorative Dentistry Araraquara Dental School UNESP - São Paulo State University
dc.description.affiliationDepartment of Dental Materials and Prosthesis Araraquara Dental School UNESP - São Paulo State University
dc.description.affiliationUnespDepartment of Restorative Dentistry Araraquara Dental School UNESP - São Paulo State University
dc.description.affiliationUnespDepartment of Dental Materials and Prosthesis Araraquara Dental School UNESP - São Paulo State University
dc.format.extent29-38
dc.identifierhttp://dx.doi.org/10.1590/0103-6440202304974
dc.identifier.citationBrazilian dental journal, v. 34, n. 1, p. 29-38, 2023.
dc.identifier.doi10.1590/0103-6440202304974
dc.identifier.issn1806-4760
dc.identifier.scopus2-s2.0-85149625097
dc.identifier.urihttp://hdl.handle.net/11449/248479
dc.language.isoeng
dc.relation.ispartofBrazilian dental journal
dc.sourceScopus
dc.titlePhysicochemical properties, cytotoxicity and bioactivity of a ready-to-use bioceramic repair materialen
dc.typeArtigo
unesp.author.orcid0000-0002-2543-5743[1]
unesp.author.orcid0000-0002-1609-2507[2]
unesp.author.orcid0000-0002-0631-3249[3]
unesp.author.orcid0000-0002-1910-2360[4]
unesp.author.orcid0000-0003-0446-2037[5]
unesp.author.orcid0000-0002-2574-4706[6]

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Artigos - Odontologia Restauradora - FOAR
Artigos - Materiais Odontológicos e Prótese - FOAR