Novel chemically modified bacterial cellulose nanocomposite as potential biomaterial for stem cell therapy applications

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dc.contributor.authorAcasigua, Gerson Arisoly Xavier
dc.contributor.authorde Olyveira, Gabriel Molina [UNESP]
dc.contributor.authorCosta, Ligia Maria Manzine
dc.contributor.authorBraghirolli, Daikelly Iglesias
dc.contributor.authorFossati, Anna Christina Medeiros
dc.contributor.authorGuastaldi, Antonio Carlos [UNESP]
dc.contributor.authorPranke, Patricia
dc.contributor.authorDaltro, Gildásio de Cerqueira
dc.contributor.authorBasmaji, Pierre
dc.contributor.institutionFederal University of Rio Grande do Sul-UFRGS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUFRGS
dc.contributor.institutionStem Cell Research Institute (SCRI)
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionInnovatec's - Biotechnology Research and Development
dc.date.accessioned2018-12-11T16:55:29Z
dc.date.available2018-12-11T16:55:29Z
dc.date.issued2014-01-01
dc.description.abstractBacterial cellulose (BC) has become established as a remarkably versatile biomaterial and can be used in a wide variety of applied scientific applications, especially for medical devices. In this work, the bacterial cellulose fermentation process is modified by the addition of hyaluronic acid and gelatin (1% w/w) to the culture medium before the bacteria is inoculated. Hyaluronic acid and gelatin influence in bacterial cellulose was analyzed using Transmission Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). Adhesion and viability studies with human dental pulp stem cells using natural bacterial cellulose/hyaluronic acid as scaffolds for regenerative medicine are presented for the first time in this work. MTT viability assays show higher cell adhesion in bacterial cellulose/gelatin and bacterial cellulose/ hyaluronic acid scaffolds over time with differences due to fiber agglomeration in bacterial cellulose/gelatin. Confocal microscopy images showed that the cell were adhered and well distributed within the fibers in both types of scaffolds. © 2014 Bentham Science Publishers.en
dc.description.affiliationPost-graduate Program in Dentistry Federal University of Rio Grande do Sul-UFRGS, Porto Alegre-RS, 90610-000
dc.description.affiliationDepartment of Physical Chemistry UNESP, Araraquara-SP, 14800-900
dc.description.affiliationDepartment of Nanoscience and Advanced Materials UFABC, Santo André-SP, 09210-170
dc.description.affiliationHematology and Stem Cell Laboratory Federal University of Rio Grande do Sul UFRGS, Porto Alegre-RS, 90610-000
dc.description.affiliationPost-graduate Program in Physiology Federal University of Rio Grande do Sul-UFRGS, Porto Alegre-RS, 90610-000
dc.description.affiliationStem Cell Research Institute (SCRI), Porto Alegre-RS, 90610-000
dc.description.affiliationCollege Hospital Complex Prof. Edgard Santos (COM-HUPES) UFBA, Salvador, 40110-910
dc.description.affiliationInnovatec's - Biotechnology Research and Development, São Carlos-SP, 13560-042
dc.description.affiliationUnespDepartment of Physical Chemistry UNESP, Araraquara-SP, 14800-900
dc.format.extent117-123
dc.identifierhttp://dx.doi.org/10.2174/1574888X08666131124135654
dc.identifier.citationCurrent Stem Cell Research and Therapy, v. 9, n. 2, p. 117-123, 2014.
dc.identifier.doi10.2174/1574888X08666131124135654
dc.identifier.issn1574-888X
dc.identifier.scopus2-s2.0-84893003259
dc.identifier.urihttp://hdl.handle.net/11449/171476
dc.language.isoeng
dc.relation.ispartofCurrent Stem Cell Research and Therapy
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBacterial cellulose
dc.subjectCell viability study
dc.subjectNanoskin®
dc.subjectNatural nanocomposites
dc.subjectRegenerative medicine
dc.subjectStem cells
dc.titleNovel chemically modified bacterial cellulose nanocomposite as potential biomaterial for stem cell therapy applicationsen
dc.typeArtigo
unesp.author.lattes6443430122330366[6]
unesp.author.orcid0000-0002-6433-3555[6]

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