Cardiovascular and autonomic alterations in rats with parkinsonism induced by 6-OHDA and treated with L-DOPA

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dc.contributor.authorSilva, A. S.
dc.contributor.authorAriza, Deborah
dc.contributor.authorDias, Daniel Penteado Martins
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.authorMartins-Pinge, Marli C.
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-08-06T16:13:51Z
dc.date.available2015-08-06T16:13:51Z
dc.date.issued2015
dc.description.abstractEvaluate the effects caused by L-DOPA on cardiovascular and autonomic parameters in an animal model of Parkinsonism induced by 6-hydroxydopamine (6-OHDA).Adult male Wistar rats were subjected to bilateral microinfusion of 6-OHDA or saline (sham group) in the substantia nigra, and treated by gavage with L-DOPA or water for 7days after surgery. On the 6th day the rats were subjected to femoral artery catheterization for cardiovascular recording. Mean arterial pressure (MAP) and heart rate (HR) were evaluated at baseline and during head up tilt (HUT) protocol. Spectral analysis of cardiovascular variability was performed using the V2.4 CardioSeries software v2.4. The lesion was quantified by dopamine levels in the striatum.Dopamine levels in the striatum were decreased in 6-OHDA rats (sham: 4.79±0.49ng/mg; 6-OHDA: 1.99±0.68ng/mg) and were not recovered by Prolopa treatment. Baseline values of MAP and HR were not different between groups. HUT induced an increase in MAP and HR (ΔMAP: 17±1mmHg, ΔHR: 39±4bpm) that were attenuated in 6-OHDA and in Prolopa treated animals. At baseline, the systolic arterial pressure (SAP) variance was lower in the 6-OHDA and sham Prolopa groups. Spontaneous baroreflex sensitivity was higher at baseline in the 6-OHDA group as compared to all studied groups.Our data suggest that treatment with Prolopa did not interfere with cardiovascular variables at baseline. However, during HUT, the 6-OHDA and Prolopa control animals presented a lower cardiovascular compensation, suggesting a possible autonomic impairment in Parkinsonism induced by 6-OHDA.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Princípios Ativos Naturais e Toxicologia, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jau Km 01, Campus Universitário, CEP 14801902, SP, Brasil
dc.description.affiliationDepartamento de Ciências Fisiológicas, Universidade Estadual de Londrina — UEL, Londrina, PR, Brazil
dc.description.affiliationUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Fisiologia, Laboratório de Fisiologia Cardiovascular, Ribeirão Preto, SP, Brazil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Princípios Ativos Naturais e Toxicologia, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jau Km 01, Campus Universitário, CEP 14801902, SP, Brasil
dc.format.extent82-89
dc.identifierhttps://www.infona.pl/resource/bwmeta1.element.elsevier-8a25529f-25aa-3c88-ac0a-4ee0a7a90bb4/tab/summary
dc.identifier.citationLife Sciences, v. 127, p. 82-89, 2015.
dc.identifier.doi10.1016/j.lfs.2015.01.032
dc.identifier.issn0024-3205
dc.identifier.lattes1117432571971568
dc.identifier.urihttp://hdl.handle.net/11449/126064
dc.language.isoeng
dc.relation.ispartofLife Sciences
dc.relation.ispartofjcr3.234
dc.relation.ispartofsjr1,071
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectArterial pressureen
dc.subjectHeart rateen
dc.subjectVariabilityen
dc.subjectProlopaen
dc.subjectHead up tilten
dc.titleCardiovascular and autonomic alterations in rats with parkinsonism induced by 6-OHDA and treated with L-DOPAen
dc.typeArtigo
unesp.author.lattes1117432571971568[4]
unesp.author.orcid0000-0002-1942-858X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas