Analytical Methods for the Determination of Chlorhexidine: A Review

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dc.contributor.authorMasquio Fiorentino, Flavia Angelica [UNESP]
dc.contributor.authorCorrea, Marcos Antonio [UNESP]
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:52Z
dc.date.available2014-05-20T13:24:52Z
dc.date.issued2010-01-01
dc.description.abstractChlorhexidine is a type of antiseptic belonging to biguanidic group and it is large, used in dentistry, human, and veterinary medicine because it is active against Gram-positive and Gram-negative microorganisms. It can be incorporated in several types of preparations and for this reason are necessary effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies. Chlorhexidine can be analyzed by many types of assays, however the HPLC is the most used method. In this review, various methods to analyze chlorhexidine including spectrometry, chromatography, colorimetric reaction, solid phase extraction, and capillary electrophoresis are presented and the application of these methods for the determination of chlorhexidine in biological fluids and formulations are discussed.en
dc.description.affiliationUNESP, Fac Ciencias Farmaceut Araraquara, Programa Posgrad Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Fac Ciencias Farmaceut Araraquara, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut Araraquara, Programa Posgrad Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut Araraquara, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent89-101
dc.identifierhttp://dx.doi.org/10.1080/10408340903232020
dc.identifier.citationCritical Reviews In Analytical Chemistry. Philadelphia: Taylor & Francis Inc, v. 40, n. 2, p. 89-101, 2010.
dc.identifier.doi10.1080/10408340903232020
dc.identifier.issn1040-8347
dc.identifier.lattes3316011688829943
dc.identifier.urihttp://hdl.handle.net/11449/7834
dc.identifier.wosWOS:000277518600003
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofCritical Reviews in Analytical Chemistry
dc.relation.ispartofjcr3.231
dc.relation.ispartofsjr0,819
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectreviewen
dc.subjectchlorhexidineen
dc.subjectmethods of analysisen
dc.titleAnalytical Methods for the Determination of Chlorhexidine: A Reviewen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.lattes3316011688829943
unesp.author.orcid0000-0002-0385-340X[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas