Genetic variability of inflammatory genes in the brazilian population

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dc.contributor.authorSantos, Marcelo
dc.contributor.authorSturr, Elaine
dc.contributor.authorMaia, Lucas Lima
dc.contributor.authorAgostini, Lidiane Pignaton
dc.contributor.authorPeterle, Gabriela Tonini
dc.contributor.authorMendes, Suzanny Oliveira
dc.contributor.authorSilva, Eloiza Helena Tajara da [UNESP]
dc.contributor.authorCarvalho, Marcos Brasilino
dc.contributor.authorLouro, Iúri Drumond
dc.contributor.authorSilva-Conforti, Adriana Madeira Álvares da
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-04-27T11:55:47Z
dc.date.available2015-04-27T11:55:47Z
dc.date.issued2013
dc.description.abstractInflammatory gene variants have been associated with several diseases, including cancer, diabetes, vascular diseases, neurodegenerative diseases, arthritis, and others. Therefore, determining the population genetic composition of inflammation-related genes can be useful for the determination of general risk, prognostic and therapeutic strategies to prevent or cure specific diseases. We have aimed to identify polymorphism genotype frequencies in genes related to the inflammatory response in the Brazilian population, namely, IjBL - 62AT, IjBL - 262CT, tumor necrosis factors alpha (TNFa) - 238GA, TNFa - 308GA, lymphotoxin-alpha (LTa) + 80AC, LTa + 252AG, FAS - 670AG, and FASL - 844TC, considering the white, black, and Pardo ethnicities of the Sa˜o Paulo State. Our results suggest that the Brazilian population is under a miscegenation process at the current time, since some genotypes are not in the Hardy–Weinberg equilibrium. In addition, we conclude that the Pardo ethnicity is derived from a complex mixture of ethnicities, including the native Indian population.en
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Estudos Lingüísticos e Literários, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, Rua Cristóvão Colombo, 2265 - sala 22 - Departamento de Estudos Lingüísticos e Literários, Jardim Nazareth, CEP 15054-000, SP, Brasil
dc.description.affiliationUnespPrograma de Pós Graduação em Biotecnologia, Universidade Federal do Espírito Santo, Vitória, Espírito Santo, Brazil
dc.description.affiliationUnespLaboratório de Biologia Molecular, Hospital Heliópolis, São Paulo, Brazil
dc.description.affiliationUnespNúcleo de Gene´tica Humana e Molecular, Departamento de Cieˆncias Biolo´gicas, Universidade Federal do Espı´rito Santo, Vito´ria, Espı´rito Santo, Brazil
dc.description.affiliationUnespDepartamento de Biologia, Universidade Federal do Espı´rito Santo, Alegre, Espı´rito Santo, Brazil
dc.format.extent844-848
dc.identifierhttp://online.liebertpub.com/doi/abs/10.1089/gtmb.2013.0264
dc.identifier.citationGenetic Testing and Molecular Biomarkers, v. 17, n. 11, p. 844-848, 2013.
dc.identifier.doi10.1089/gtmb.2013.0264
dc.identifier.issn1945-0265
dc.identifier.lattes8102755896732025
dc.identifier.lattes3667257393072255
dc.identifier.urihttp://hdl.handle.net/11449/122481
dc.language.isoeng
dc.relation.ispartofGenetic Testing and Molecular Biomarkers
dc.relation.ispartofjcr1.181
dc.relation.ispartofsjr0,507
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.titleGenetic variability of inflammatory genes in the brazilian populationen
dc.typeArtigo
unesp.author.lattes8102755896732025
unesp.author.lattes3667257393072255
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologia Molecularpt

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