Time-dependent alterations of soluble and cellular components in human milk

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dc.contributor.authorFranca, Eduardo Luzia
dc.contributor.authorNicomedes, Tathianne dos Reis
dc.contributor.authorCalderon, Iracema de Mattos Paranhos [UNESP]
dc.contributor.authorHonorio Franca, Adenilda Cristina
dc.contributor.institutionUniv Fed Mato Grosso
dc.contributor.institutionHuman Milk Bank Attent Ctr Women
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:35:33Z
dc.date.available2014-05-20T13:35:33Z
dc.date.issued2010-01-01
dc.description.abstractThis study sought to determine the chronobiological variations in soluble and cellular components of human breast milk. The material was collected from 36 mothers at three stages of maturity - 3 days (colostrum), 10 days (transitional milk) and 30 days (mature milk) postpartum - and at two times of day - diurnal (12:00 h) and nocturnal (24: 00 h) - making a total of 216 samples. Fat and calorie content, antibody concentration, C3 and C4 proteins of the complement system, superoxide anion release by milk mononuclear (MN) and polymorphonuclear (PMN) phagocytes, and concentration of the superoxide dismutase enzyme (CuZn-SOD) were determined. No difference in fat concentration was found between milk collected at the different times or between milk maturation stages but in the transitional milk the calorie concentration was higher in the nocturnal period. IgA was higher in milk collected in the diurnal period regardless of milk maturation. IgG and IgM were at higher concentrations in the diurnal period for both transitional and mature milk. The C3 protein increased significantly in the diurnal period regardless of milk maturation, and the C4 protein increased significantly during the diurnal period in the colostrum and transitional milk stages. Mature milk MN phagocytes had the highest superoxide during the diurnal period. Superoxide release by PMN phagocytes was higher in colostrum and mature milk collected in the diurnal period. CuZn-SOD increased significantly in diurnal and nocturnal colostrum. This chronobiological variation during the first month postpartum may represent an additional breastfeeding mechanism to improve adaptation to environmental changes and establish biological rhythms in the temporal synchronization process.en
dc.description.affiliationUniv Fed Mato Grosso, Inst Biol & Hlth Sci, Pontal do Araguaia, MT, Brazil
dc.description.affiliationHuman Milk Bank Attent Ctr Women, Araxa, MG, Brazil
dc.description.affiliationSão Paulo State Univ Unesp, Post Grad Program Gynecol Obstet & Mastol, Botucatu Med Sch, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ Unesp, Post Grad Program Gynecol Obstet & Mastol, Botucatu Med Sch, São Paulo, Brazil
dc.description.sponsorshipSão Paulo State University (UNESP), São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 08/09187-8
dc.format.extent333-347
dc.identifierhttp://dx.doi.org/10.1080/09291010903407441
dc.identifier.citationBiological Rhythm Research. Abingdon: Taylor & Francis Ltd, v. 41, n. 5, p. 333-347, 2010.
dc.identifier.doi10.1080/09291010903407441
dc.identifier.issn0929-1016
dc.identifier.lattes0679387622604743
dc.identifier.urihttp://hdl.handle.net/11449/12246
dc.identifier.wosWOS:000282660800002
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiological Rhythm Research
dc.relation.ispartofjcr0.699
dc.relation.ispartofsjr0,242
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjecthuman milken
dc.subjectcolostrum phagocytesen
dc.subjectbiological rhythmsen
dc.subjectsuperoxide anionen
dc.subjectantibodyen
dc.titleTime-dependent alterations of soluble and cellular components in human milken
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd
unesp.author.lattes0679387622604743
unesp.author.orcid0000-0003-4761-4336[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentGinecologia e Obstetrícia - FMBpt

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Botucatu - FMB - Faculdade de Medicina