EGFR amplification and expression in oral squamous cell carcinoma in young adults

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dc.contributor.authorCosta, V. [UNESP]
dc.contributor.authorKowalski, L. P.
dc.contributor.authorCoutinho-Camillo, C. M.
dc.contributor.authorBegnami, M. D.
dc.contributor.authorCalsavara, V. F.
dc.contributor.authorNeves, J. I.
dc.contributor.authorKaminagakura, E. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionA.C. Camargo Cancer Center
dc.contributor.institutionA.C. Camargo Cancer Centre
dc.date.accessioned2018-12-11T16:51:33Z
dc.date.available2018-12-11T16:51:33Z
dc.date.issued2018-07-01
dc.description.abstractThe aim of this study was to investigate epidermal growth factor receptor (EGFR) gene alterations in two groups of patients with oral squamous cell carcinoma (OSCC) (a test group of subjects aged ≤40 years and a control group of subjects aged ≥50 years) and to associate the results with EGFR immunostaining, clinicopathological features, and the prognosis. Sixty cases of OSCC were selected (test group, n = 21; control group, n = 39). The tissue microarray technique was applied to ensure the uniformity of results. Gene amplification was analyzed by fluorescence in situ hybridization (FISH), and immunohistochemical staining for EGFR was analyzed using an automated imaging system. EGFR amplification was higher in the test group than in the control group (P = 0.018) and was associated with advanced clinical stage (P = 0.013), regardless of age. Patients with EGFR overexpression had worse survival rates, as did patients who had T3–T4 tumours and positive margins. EGFR overexpression has a negative impact on disease progression. Despite the higher amplification of EGFR in young adults, it does not significantly impact the survival rates of affected patients.en
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp)
dc.description.affiliationDepartment of Head and Neck Surgery and Otorhinolaryngology A.C. Camargo Cancer Center
dc.description.affiliationInternational Research Centre A.C. Camargo Cancer Centre
dc.description.affiliationDepartment of Anatomic Pathology A.C. Camargo Cancer Center
dc.description.affiliationDepartment of Epidemiology and Statistics A.C. Camargo Cancer Center
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Amazonas
dc.description.sponsorshipIdFAPESP: 12/21660-6
dc.description.sponsorshipIdFundação de Amparo à Pesquisa do Estado do Amazonas: 254/2014
dc.format.extent817-823
dc.identifierhttp://dx.doi.org/10.1016/j.ijom.2018.01.002
dc.identifier.citationInternational Journal of Oral and Maxillofacial Surgery, v. 47, n. 7, p. 817-823, 2018.
dc.identifier.doi10.1016/j.ijom.2018.01.002
dc.identifier.file2-s2.0-85041074409.pdf
dc.identifier.issn1399-0020
dc.identifier.issn0901-5027
dc.identifier.scopus2-s2.0-85041074409
dc.identifier.urihttp://hdl.handle.net/11449/170580
dc.language.isoeng
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgery
dc.relation.ispartofsjr1,137
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectEGFR gene
dc.subjectfluorescence in situ hybridization
dc.subjectimmunohistochemistry
dc.subjectoral cancer
dc.subjectprognosis
dc.subjectsquamous cell carcinoma
dc.titleEGFR amplification and expression in oral squamous cell carcinoma in young adultsen
dc.typeArtigo
unesp.author.orcid0000-0002-5682-5509[1]

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