Serum haptoglobin types in patients with hemoglobinopathies

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dc.contributor.authorMoreira, H. W.
dc.contributor.authorNaoum, P. C.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T10:28:46Z
dc.date.available2014-05-27T10:28:46Z
dc.date.issued1990-12-01
dc.description.abstractHaptoglobin types were determined in 626 individuals living in the State of Sao Paulo (Brazil). Of these, 484 had Hb AA, 31 major beta thalassemia, 43 minor beta thalassemia, 14 Hb SS, and 54 Hb AS. Frequency distribution of the three most common types observed among patients with type beta thalassemia differed significantly from that observed in the Caucasian group with Hb AA. There was a significant increase in Hp 1-1, which led us to assume that these disorders participate in a selective process acting on haptoglobins and altering the equilibrium of their frequencies. This relationship was not observed when we compared patients with Hb SS and Hb AS with Black patients with Hb AA, although the type most often observed among patients with Hb SS was Hp 1-1. The distributions of Hp groups observed among Caucasian and Black patients with Hb AA were similar to those obtained by other investigators for the South and Southeast regions of Brazil, with the exception of Rio de Janeiro.en
dc.format.extent227-231
dc.identifierhttp://dx.doi.org/10.1111/j.1601-5223.1990.tb00088.x
dc.identifier.citationHereditas, v. 113, n. 3, p. 227-231, 1990.
dc.identifier.doi10.1111/j.1601-5223.1990.tb00088.x
dc.identifier.file2-s2.0-0025640066.pdf
dc.identifier.issn0018-0661
dc.identifier.scopus2-s2.0-0025640066
dc.identifier.urihttp://hdl.handle.net/11449/64042
dc.language.isoeng
dc.relation.ispartofHereditas
dc.relation.ispartofsjr0,278
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjecthaptoglobin
dc.subjectbeta thalassemia
dc.subjectclinical article
dc.subjectgene frequency
dc.subjecthemoglobinopathy
dc.subjecthuman
dc.subjectrace
dc.subjectAlleles
dc.subjectBrazil
dc.subjectCaucasoid Race
dc.subjectGene Frequency
dc.subjectHaptoglobins
dc.subjectHemoglobinopathies
dc.subjectHuman
dc.subjectNegroid Race
dc.titleSerum haptoglobin types in patients with hemoglobinopathiesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html

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